ANCA-associated vasculitis has genetic component

July 19, 2012
ANCA-associated vasculitis has genetic component
A genome-wide association study of antineutrophil cytoplasmic antibody-associated vasculitis shows a genetic contribution to disease susceptibility, which differs between granulomatosis with polyangiitis and microscopic polyangiitis, according to a study published in the July 19 issue of the New England Journal of Medicine.

(HealthDay) -- A genome-wide association study of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis shows a genetic contribution to disease susceptibility, which differs between granulomatosis with polyangiitis and microscopic polyangiitis, according to a study published in the July 19 issue of the New England Journal of Medicine.

To investigate the genetic basis of ANCA-associated vasculitis, Paul A. Lyons, Ph.D., from the University of Cambridge in the United Kingdom, and colleagues conducted a genome-wide association study in a discovery cohort of 1,233 U.K. patients with ANCA-associated vasculitis and 5,884 controls. Associations were replicated in 1,454 Northern European case patients and 1,666 controls.

The researchers identified major-histocompatibility-complex (MHC) and non-MHC associations with ANCA-associated vasculitis. In addition, genetic distinctions were seen for granulomatosis with polyangiitis and microscopic polyangiitis. The strongest were not with the clinical syndrome, but with the antigenic specificity of ANCA. Anti-proteinase 3 ANCA correlated significantly with HLA-DP and the genes encoding α1-antitrypsin (SERPINA1) and proteinase 3 (PRTN3). There was also a significant association between anti-myeloperoxidase ANCA and HLA-DQ.

"This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyangiitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature of proteinase 3 ANCA-associated vasculitis," Lyons and colleagues conclude.

Several study authors and the editorial author disclosed financial ties to the pharmaceutical industry.

Explore further: Long-term rituximab safe for patients with wegener's

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Long-term rituximab safe for patients with wegener's

July 2, 2012
(HealthDay) -- Repeated and prolonged use of rituximab for B-cell depletion to treat relapses or maintain remission is safe and effective in patients with refractory granulomatosis with polyangiitis (GPA; Wegener's), a primary ...

Why some kidney disease patients can't repair blood vessels

October 27, 2011
In some kidney diseases, patients have high blood levels of a protein that blocks blood vessel repair, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). Inhibiting ...

Stress triggers disease flares in patients with vasculitis

November 6, 2011
In patients with a devastating form of vasculitis who are in remission, stress can be associated with a greater likelihood of the disease flaring, according to a new study by investigators at Hospital for Special Surgery ...

Recommended for you

Association found between abnormal cerebral connectivity and variability in the PPARG gene in developing preterm infants

December 12, 2017
(Medical Xpress)—A team of researchers with King's College London and the National Institute for Health Research Biomedical Research Centre, both in the U.K., has found what they describe as a strong association between ...

Large genetic study links tendency to undervalue future rewards with ADHD, obesity

December 11, 2017
Researchers at University of California San Diego School of Medicine have found a genetic signature for delay discounting—the tendency to undervalue future rewards—that overlaps with attention-deficit/hyperactivity disorder ...

Gene variants identified that may influence sexual orientation in men and boys

December 8, 2017
(Medical Xpress)—A large team of researchers from several institutions in the U.S. and one each from Australia and the U.K. has found two gene variants that appear to be more prevalent in gay men than straight men, adding ...

Disease caused by reduction of most abundant cellular protein identified

December 8, 2017
An international team of scientists and doctors has identified a new disease that results in low levels of a common protein found inside our cells.

Study finds genetic mutation causes 'vicious cycle' in most common form of amyotrophic lateral sclerosis

December 8, 2017
University of Michigan-led research brings scientists one step closer to understanding the development of neurodegenerative disorders such as ALS.

Mutations in neurons accumulate as we age: The process may explain normal cognitive decline and neurodegeneration

December 7, 2017
Scientists have wondered whether somatic (non-inherited) mutations play a role in aging and brain degeneration, but until recently there was no good technology to test this idea. A study published online today in Science, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.