New study announced that will use genetics to test for Alzheimer's risk

July 19, 2012, Brigham and Women's Hospital

In a new Alzheimer's disease risk assessment study unveiled this week during the Alzheimer's Association International Conference, researchers at Brigham and Women's Hospital (BWH) are offering genetic testing and Alzheimer's risk estimates for people who are experiencing mild cognitive impairment.

The Risk Evaluation and Education for Alzheimer's Disease Study (REVEAL) is a multi-center randomized funded by the National Institutes of Health and led by Robert C. Green, MD, MPH, a physician-scientist in the Division of Genetics at BWH.

"We are on the brink of developing disease modifying treatments and to combat Alzheimer's disease," Green said. "As health professionals begin to put these discoveries into medical practice, they will need to communicate complex risk information to individuals and their families. We expect that the REVEAL study will provide accurate guidance for estimating and communicating risk information to individuals, and we hope that results from REVEAL will inform the future practice of treating individuals at risk for Alzheimer's disease."

The goal of the REVEAL study is to determine how people with mild cognitive impairment and their caregivers respond to health education and . Researchers will evaluate how well participants understand the Alzheimer's risk assessment materials and the implications of the genetic test. After the results are returned to the participants, researchers will monitor how participants adjust psychologically and what they make in response to the new information.

Mild cognitive impairment is a common condition where those affected have noticeable memory and thinking problems but can still carry out their usual activities. People with mild cognitive impairment are at elevated risk for developing Alzheimer's disease, so it is important to evaluate the different methods of providing risk information for Alzheimer's, including genetic testing, to those individuals and their loved ones. REVEAL participants will have the opportunity to learn what it means to have , what their chances are of developing Alzheimer's and how to cope with problems related to memory loss. Researchers will follow up with participants for a period of six months after the risk assessment is received.

Explore further: People with early Alzheimer's disease may be more likely to have lower BMI

Related Stories

People with early Alzheimer's disease may be more likely to have lower BMI

November 21, 2011
Studies have shown that people who are overweight in middle age are more likely to develop Alzheimer's disease decades later than people at normal weight, yet researchers have also found that people in the earliest stages ...

Treating high blood pressure, cholesterol, diabetes may lower risk of Alzheimer's disease

April 13, 2011
Treating high blood pressure, high cholesterol, diabetes and other vascular risk factors may help lower the risk of Alzheimer's disease in people who already show signs of declining thinking skills or memory problems. The ...

Recommended for you

Rocky start for Alzheimer's drug research in 2018

January 19, 2018
The year 2018, barely underway, has already dealt a series of disheartening blows to the quest for an Alzheimer's cure.

Alzheimer's disease: Neuronal loss very limited

January 17, 2018
Frequently encountered in the elderly, Alzheimer's is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint ...

Anxiety: An early indicator of Alzheimer's disease?

January 12, 2018
A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of ...

One of the most promising drugs for Alzheimer's disease fails in clinical trials

January 11, 2018
To the roughly 400 clinical trials that have tested some experimental treatment for Alzheimer's disease and come up short, we can now add three more.

Different disease types associated with distinct amyloid-beta prion strains found in Alzheimer's patients

January 9, 2018
An international team of researchers has found different disease type associations with distinct amyloid-beta prion strains in the brains of dead Alzheimer's patients. In their paper published in Proceedings of the National ...

Advances in brain imaging settle debate over spread of key protein in Alzheimer's

January 5, 2018
Recent advances in brain imaging have enabled scientists to show for the first time that a key protein which causes nerve cell death spreads throughout the brain in Alzheimer's disease - and hence that blocking its spread ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.