Human papillomavirus types do not replace others after large-scale vaccination

July 24, 2012

Vaccines against human papillomavirus (HPV) are now recommended by the Centers for Disease Control and Prevention for both teenage boys and girls. The vaccine protects against the two most common types of the virus that cause cervical cancer: HPV 16 and 18. Is there a chance that the increased number of people vaccinated might result in an increase of other types of HPV that cause cancer?

A UNC-led international team of scientists studied this question in a group of 2228 Kenyan men as a "nested" trial in a larger trial. Their first paper in the showed that little evidence exists for potential type competition in a cross-sectional study. Viral type competition occurs when different types of a particular virus compete for dominance.

Their new work is reported in the June 18, 2012 early online issue of the Journal of Infectious Diseases. Using prospective data, their study presents the first epidemiological data in men on the type-specific associations between prevalent and future acquisition of other HPV types.

Jennifer Smith, PhD, MPH, study senior author explains, "We found no evidence for competition between different HPV types over time in high-risk men from Kenya. While these data are based only on non-vaccinated men, our findings are of potential importance because they suggest that HPV types are generally acting independently from one another, and thus it is unlikely that HPV type-replacement will occur following large scale vaccination programs of young male adolescents."

Dr. Smith is an associate professor of epidemiology in the UNC Gillings School of Global Public Health and a member of UNC Lineberger Comprehensive Cancer Center.

With the recent approval of prophylactic HPV vaccination of young men, data are needed to understand if patterns of HPV acquisition differ among men with specific HPV type infections as compared to without these HPV infections. The effect of current vaccine-relevant HPV infections on the subsequent acquisition of different HPV types could impact the long-term potential for HPV type replacement following population-based HPV vaccination.

Explore further: No evidence for potential competition between human papillomavirus types in men

Related Stories

No evidence for potential competition between human papillomavirus types in men

November 14, 2011
The Centers for Disease Control and Prevention Advisory Committee on Immunization Practices recently recommended that teenage boys be vaccinated against the human papillomavirus.

Male circumcision lowers prevalence of penile precancerous lesions among African men

July 28, 2011
A University of North Carolina-led international study shows that among Kenyan men, circumcision is associated with a lower prevalence of human papillomavirus-associated precancerous lesions of the penis. Human papillomavirus ...

Oral HPV infection, HPV-related cancers more common in men

January 26, 2012
Oral HPV infection is more common among men than women, explaining why men are more prone than women to develop an HPV related head and neck cancer, according to a study presented at the Multidisciplinary Head and Neck Cancer ...

Recommended for you

Google searches can be used to track dengue in underdeveloped countries

July 20, 2017
An analytical tool that combines Google search data with government-provided clinical data can quickly and accurately track dengue fever in less-developed countries, according to new research published in PLOS Computational ...

MRSA emerged years before methicillin was even discovered

July 19, 2017
Methicillin resistant Staphylococcus aureus (MRSA) emerged long before the introduction of the antibiotic methicillin into clinical practice, according to a study published in the open access journal Genome Biology. It was ...

New test distinguishes Zika from similar viral infections

July 18, 2017
A new test is the best-to-date in differentiating Zika virus infections from infections caused by similar viruses. The antibody-based assay, developed by researchers at UC Berkeley and Humabs BioMed, a private biotechnology ...

'Superbugs' study reveals complex picture of E. coli bloodstream infections

July 18, 2017
The first large-scale genetic study of Escherichia coli (E. coli) cultured from patients with bloodstream infections in England showed that drug resistant 'superbugs' are not always out-competing other strains. Research by ...

Ebola virus can persist in monkeys that survived disease, even after symptoms disappear

July 17, 2017
Ebola virus infection can be detected in rhesus monkeys that survive the disease and no longer show symptoms, according to research published by Army scientists in today's online edition of the journal Nature Microbiology. ...

Mountain gorillas have herpes virus similar to that found in humans

July 13, 2017
Scientists from the University of California, Davis, have detected a herpes virus in wild mountain gorillas that is very similar to the Epstein-Barr virus in humans, according to a study published today in the journal Scientific ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.