New vaccine for renal cell carcinoma found to increase survival rates

July 30, 2012 by Bob Yirka report

(Medical Xpress) -- Researchers working for German pharmaceutical company Immatics Biotechnologies GmbH, have outlined two successful outcomes for their multipeptide vaccine IMA901 in a paper they’ve had published in the journal Nature Medicine. In it they describe how renal cell carcinoma (RCC) patients vaccinated with IMA901 experienced longer survival rates and how they’ve also discovered key markers that they believe indicate which patients are most likely to benefit from the vaccine.

RCC, also known as hypernephroma, is the most common type of kidney cancer and survival rates for those who get it are low if the cancer metastases. Current treatment usually means removal of the cancerous tissue along with various forms of immunotherapy as radiation and chemotherapy are generally ineffective. Immunotherapy involves administering drugs that help the body identify cancerous cells as something that needs to be attacked and killed. To date, unfortunately, progress in this area of medicine has been slow, thus, the news that the vaccine developed my Immatics is showing some success is generating excitement in the cancer research world.

RCC vaccines are therapeutic, not preventative, hence they are only administered to people who have already been diagnosed. IMA901 was developed by noting the different antigens that come to exist on or around tumors as a result of the growth of cancerous cells under certain circumstances. The is made up of ten peptides that the research team has found cause stimulation of the immune system in patients that express the antigens they’ve noted. That in turn causes the immune system to go on alert and to attack the tumors and hopefully kill them in the process.

IMA901 has currently gone through phase 1 and 2 clinical trials and is currently in phase 3. In the first two phases, the team found longer survival rates for the patients who volunteered to take part in the testing. Survival rates for those who undergo current treatment therapies are typically sixty to seventy percent for five years.

The team also detailed two serum biomarkers they’ve discovered that they believe signal which RCC patients would be the most likely to benefit from IMA901, though they note that they won’t know for sure how accurate they are until completion of phase 3 of their clinical trials.

Explore further: Novel brain tumor vaccine acts like bloodhound to locate cancer cells

More information: Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival, Nature Medicine (2012) doi:10.1038/nm.2883

Abstract
IMA901 is the first therapeutic vaccine for renal cell cancer (RCC) consisting of multiple tumor-associated peptides (TUMAPs) confirmed to be naturally presented in human cancer tissue. We treated a total of 96 human leukocyte antigen A (HLA-A)*02+ subjects with advanced RCC with IMA901 in two consecutive studies. In the phase 1 study, the T cell responses of the patients to multiple TUMAPs were associated with better disease control and lower numbers of prevaccine forkhead box P3 (FOXP3)+ regulatory T (Treg) cells. The randomized phase 2 trial showed that a single dose of cyclophosphamide reduced the number of Treg cells and confirmed that immune responses to multiple TUMAPs were associated with longer overall survival. Furthermore, among six predefined populations of myeloid-derived suppressor cells, two were prognostic for overall survival, and among over 300 serum biomarkers, we identified apolipoprotein A-I (APOA1) and chemokine (C-C motif) ligand 17 (CCL17) as being predictive for both immune response to IMA901 and overall survival. A randomized phase 3 study to determine the clinical benefit of treatment with IMA901 is ongoing.

Related Stories

Novel brain tumor vaccine acts like bloodhound to locate cancer cells

January 5, 2012
A national clinical trial testing the efficacy of a novel brain tumor vaccine has begun at Wake Forest Baptist Medical Center, the only facility in the Southeast to participate.

Cuba releases world's first lung cancer vaccine

September 8, 2011
(Medical Xpress) -- As the most common and deadliest form of cancer, lung cancer kills 1.4 million people per year worldwide, according to the World Health Organization. While current treatments may improve the survival rate ...

Lymphocyte count indicates the prognosis of patients with renal cell carcinoma

June 1, 2011
Each year, kidney cancer is diagnosed in nearly 60,000 people in the U.S. Many of these patients undergo surgery to remove the affected kidney, but this procedure can be risky for the elderly and those who have other health ...

Cancer vaccine combination therapy shows survival benefit in breast cancer

May 15, 2012
A vaccine that targets cancer cells in combination with the drug letrozole, a standard hormonal therapy against breast cancer, significantly increased survival when tested in mice, a team of UC Davis investigators has found.

Researchers discover that lymphocyte count indicates prognosis of patients with renal cell carcinoma

May 18, 2011
Each year, kidney cancer is diagnosed in nearly 60,000 people in the U.S. Many of these patients undergo surgery to remove the affected kidney, but this procedure can be risky for the elderly and those who have other health ...

Recommended for you

New therapeutic approach for difficult-to-treat subtype of ovarian cancer identified

July 24, 2017
A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.

Immune cells the missing ingredient in new bladder cancer treatment

July 24, 2017
New research offers a possible explanation for why a new type of cancer treatment hasn't been working as expected against bladder cancer.

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

Discovery could lead to better results for patients undergoing radiation

July 19, 2017
More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

dlr
not rated yet Jul 31, 2012
The article says the team found longer survival rates for the patients who volunteered to take part in the testing, but it doesn't say how much longer? How much longer do the people live? On average a couple of extra weeks, or 10 more years? The size of the effect is basic information that should be included. Very poor reporting.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.