Genetic factors identified in female sexual dysfunction

August 13, 2012
Genetic factors identified in female sexual dysfunction
At least two genetic factors are involved in female sexual disorder symptomatology in addition to non-shared environmental effects, according to the results of a twin study published online Aug. 2 in The Journal of Sexual Medicine.

(HealthDay) -- At least two genetic factors are involved in female sexual disorder (FSD) symptomatology in addition to non-shared environmental effects, according to the results of a twin study published online Aug. 2 in The Journal of Sexual Medicine.

Andrea Burri, Ph.D., of King's College London, and colleagues conducted a study involving 1,489 female twins aged 18 to 85 years to determine the genetic and associated with the major subtypes of FSD. The participants included 244 monozygotic twin pairs, 189 dizygotic ; and 623 women who participated without their co-twin.

The researchers found that the model which best fit FSD was an ACE Cholesky model, which included additive genetic effects and non-shared environmental effects. Significant genetic sharing was seen between desire, arousal, lubrication, and orgasm, in addition to genetic sharing between arousal, lubrication, and orgasm, which was independent of desire. These effects were small to modest (7 to 33 percent). A third of the covariance between these dimensions was suggested to be genetic, based on bivariate heritabilities. Lubrication and orgasm shared the least amount of genetic correlation with desire. Non-shared environmental effects were stronger than genetic effects and more dimension-specific.

"In conclusion, our results show FSD to be etiologically heterogeneous in terms of its underlying genetic and environmental factor structure," the authors write. "Specific sexual dimensions were found to be influenced by two common as well as relatively dimension-specific non-shared environmental factors."

Explore further: Study finds link between relationship style and sexual dysfunction

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study finds link between relationship style and sexual dysfunction

March 7, 2012
(Medical Xpress) -- Deakin University research has shown that being too needy or not needy enough in a relationship can result in sexual issues.

Sexual satisfaction in women increases with age

January 3, 2012
A new study of sexually active older women has found that sexual satisfaction in women increases with age and those not engaging in sex are satisfied with their sex lives. A majority of study participants report frequent ...

Recommended for you

New gene editing approach for alpha-1 antitrypsin deficiency shows promise

October 20, 2017
A new study by scientists at UMass Medical School shows that using a technique called "nuclease-free" gene editing to correct cells with the mutation that causes a rare liver disease leads to repopulation of the diseased ...

Maternal diet may program child for disease risk, but better nutrition later can change that

October 20, 2017
Research has shown that a mother's diet during pregnancy, particularly one that is high-fat, may program her baby for future risk of certain diseases such as diabetes. A new study from nutrition researchers at the University ...

Researchers find evidence of DNA damage in veterans with Gulf War illness

October 19, 2017
Researchers say they have found the "first direct biological evidence" of damage in veterans with Gulf War illness to DNA within cellular structures that produce energy in the body.

Researchers drill down into gene behind frontotemporal lobar degeneration

October 19, 2017
Seven years ago, Penn Medicine researchers showed that mutations in the TMEM106B gene significantly increased a person's risk of frontotemporal lobar degeneration (FTLD), the second most common cause of dementia in those ...

New clues to treat Alagille syndrome from zebrafish

October 18, 2017
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome. The discovery, published in Nature Communications, ...

Genetic variants associated with obsessive-compulsive disorder identified

October 18, 2017
(Medical Xpress)—An international team of researchers has found evidence of four genes that can be linked to obsessive-compulsive disorder (OCD). In their paper published in the journal Nature Communications, the group ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.