High-risk HPV present in subset of penile carcinomas

August 13, 2012
High-risk HPV present in subset of penile carcinomas
High-risk human papillomavirus infection is found in a subset of penile squamous cell carcinomas that may develop from undifferentiated penile intraepithelial neoplasia, according to a study published online Aug. 6 in the Journal of the American Academy of Dermatology.

(HealthDay) -- High-risk human papillomavirus (hrHPV) infection is found in a subset of penile squamous cell carcinomas (PSCCs) that may develop from undifferentiated penile intraepithelial neoplasia (PeIN), according to a study published online Aug. 6 in the Journal of the American Academy of Dermatology.

Carla Ferrándiz-Pulido, M.D., from the Hospital Universitari Vall d'Hebron in Barcelona, Spain, and colleagues examined the prevalence of HPV in a retrospective series of 82 patients with PSCC (69 invasive and 13 PeIN). Polymerase chain reaction assay with SPF-10 broad-spectrum primers followed by DNA enzyme immunoassay was used for HPV detection, and genotyping was performed using a reverse hybridization line probe assay.

The researchers identified HPV DNA in 31 of 77 (40.2 percent) PSCC cases (22 of 67 invasive and nine of 10 PeIN). HPV-16 was identified in 25 of 31 (80.6 percent) cases. Most basaloid and warty tumors were hrHPV positive, while only 15 percent of usual PSCC were hrHPV positive. All hrHPV-positive PSCC had an adjacent undifferentiated PeIN. The researchers found that hrHPV infection correlated with strong p16INK4a immunostaining, and p16INK4a immunohistochemical overexpression was present in most undifferentiated PeIN. There was better overall survival, although not statistically significant, in both hrHPV-positive and p16INK4a-positive tumors.

"In this study, we detected hrHPV in 28 percent of PSCC and in 90 percent of PeIN," the authors write. "These results allow identification of a subset of PSCC in which HPV would play a triggering role and give support to the bimodal etiopathogenic hypothesis that distinguishes two different subsets of PSCC."

Explore further: Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers

June 18, 2012
Among patients with head and neck squamous cell carcinomas, a history of chronic inflammation in the mouth (periodontitis, i.e. gum disease) may be associated with an increased risk of tumors positive for human papillomavirus ...

Periodontitis linked to HPV-positive head, neck tumors

June 20, 2012
(HealthDay) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published ...

Prevalence of oral HPV infection higher among men than women

January 26, 2012
The overall prevalence of oral human papillomavirus (HPV) infection is approximately 7 percent among men and women ages 14 to 69 years in the United States, while the prevalence among men is higher than among women, according ...

HPV improves survival for African-Americans with throat cancer

July 19, 2012
Even though the human papillomavirus (HPV) is a risk factor for certain head and neck cancers, its presence could make all the difference in terms of survival, especially for African Americans with throat cancer, say Henry ...

Recommended for you

Study prompts new ideas on cancers' origins

December 16, 2017
Rapidly dividing, yet aberrant stem cells are a major source of cancer. But a new study suggests that mature cells also play a key role in initiating cancer—a finding that could upend the way scientists think about the ...

What does hair loss have to teach us about cancer metastasis?

December 15, 2017
Understanding how cancer cells are able to metastasize—migrate from the primary tumor to distant sites in the body—and developing therapies to inhibit this process are the focus of many laboratories around the country. ...

Cancer immunotherapy may work better in patients with specific genes

December 15, 2017
Cancer cells arise when DNA is mutated, and these cells should be recognized as "foreign" by the immune system. However, cancer cells have found ways to evade detection by the immune system.

Scientists pinpoint gene to blame for poorer survival rate in early-onset breast cancer patients

December 15, 2017
A new study led by scientists at the University of Southampton has found that inherited variation in a particular gene may be to blame for the lower survival rate of patients diagnosed with early-onset breast cancer.

Scientists unlock structure of mTOR, a key cancer cell signaling protein

December 14, 2017
Researchers in the Sloan Kettering Institute have solved the structure of an important signaling molecule in cancer cells. They used a new technology called cryo-EM to visualize the structure in three dimensions. The detailed ...

'Bet hedging' explains the efficacy of many combination cancer therapies

December 14, 2017
The efficacy of many FDA-approved cancer drug combinations is not due to synergistic interactions between drugs, but rather to a form of "bet hedging," according to a new study published by Harvard Medical School researchers ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.