Modeling metastasis

August 24, 2012, American Institute of Physics
This is an illustration of the early stage of metastasis, called "intravasation." Tumor cells (blue) in contact with the bloodstream experience shear forces that can be strong enough to exceed the adhesion forces keeping them attached to the primary tumor. Once released into the bloodstream, they become circulating tumor cells capable of spreading the disease to other sites. Credit: The University of Southern California, Oregon Health and Science University, and the Scripps Research Institute

Cancer metastasis, the escape and spread of primary tumor cells, is a common cause of cancer-related deaths. But metastasis remains poorly understood. Studies indicate that when a primary tumor breaks through a blood vessel wall, blood's "stickiness" tears off tumor cells the way a piece of tape tears wrapping paper.

Until now, no one knew the physical forces involved in this process, the first step in metastasis. Using a statistical technique employed by animators, scientists created a new computer simulation that reveals how cancer cells enter the bloodstream. The researchers present their work in a paper accepted to the (AIP) journal Physics of Fluids.

To create the simulation, a group of scientists from the University of Southern California in Los Angeles, Oregon Health and Science University in Portland, Ore., and The Scripps Research Institute in La Jolla, Calif., first had to describe the physics of the process. The researchers couldn't directly measure the fluid forces acting on a tumor cell in the body. Instead, they imaged blood flowing at different velocities over a breast cancer cell on a glass plate. Then, they bridged the gap between known and unknown with an Active Shape Model, a statistical technique that animators use to create furry monsters. Active Shape Models track the shape of an object as it dynamically deforms. When combined with the experimental data, the modeling enabled the team to compute the fluid forces acting on the cell, and that in turn helped them tune the simulation.

The study is an important first step toward understanding the mechanical properties of and how they travel over the course of the disease, the researchers say. The ultimate goal is developing of metastasis' multi-step process, and thus new therapies to target metastasis.

Explore further: New signaling pathway linked to breast cancer metastasis

Related Stories

New signaling pathway linked to breast cancer metastasis

April 2, 2012
Lymph nodes help to fight off infections by producing immune cells and filtering foreign materials from the body, such as bacteria or cancer cells. Thus, one of the first places that cancer cells are found when they leave ...

Researchers discover protein that could help prevent the spread of cancer

May 4, 2011
A protein capable of halting the spread of breast cancer cells could lead to a therapy for preventing or limiting the spread of the disease.

Crucial molecule that involved in spread of breast cancer found

June 8, 2011
Researchers at Albert Einstein College of Medicine of Yeshiva University have identified a key player in the spread of breast cancer. The findings, published today in the online edition of Nature, identify a critical molecule ...

Recommended for you

Researchers identify a protein that keeps metastatic breast cancer cells dormant

January 23, 2018
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light ...

Scientists block the siren call of two aggressive cancers

January 23, 2018
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

Workouts may boost life span after breast cancer

January 22, 2018
(HealthDay)—Longer survival after breast cancer may be as simple as staying fit, new research shows.

Cancer patients who tell their life story find more peace, less depression

January 22, 2018
Fifteen years ago, University of Wisconsin–Madison researcher Meg Wise began interviewing cancer patients nearing the end of life about how they were living with their diagnosis. She was surprised to find that many asked ...

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.