Skin intrinsic fluorescence tied to coronary artery disease

August 7, 2012
Skin intrinsic fluorescence tied to coronary artery disease
Skin intrinsic fluorescence is significantly associated with coronary artery disease in middle-aged adults with a long duration of type 1 diabetes, according to a study published online July 30 in Diabetes Care.

(HealthDay) -- Skin intrinsic fluorescence (SIF) is significantly associated with coronary artery disease (CAD) in middle-aged adults with a long duration of type 1 diabetes, according to a study published online July 30 in Diabetes Care.

Baqiyyah N. Conway, Ph.D., of Vanderbilt University in Nashville, Tenn., and colleagues conducted a study involving a total of 172 middle-aged adults with type 1 diabetes (mean disease duration, 36 years) to evaluate the relationship between SIF and CAD and whether this relationship was independent of renal disease.

The researchers found that 30 of the participants had CAD, and that SIF levels were significantly higher in those participants with CAD. SIF correlated strongly with CAD (odds ratio [OR], 3.5). The correlation persisted, after adjustment for age, diabetes duration, and cumulative glycemic exposure (OR, 2.4), and was stronger for men (OR, 5.6) than for women (OR, 1.4; 95 percent confidence interval [CI], 0.61 to 3.3). With inclusion of nephropathy in the model, the OR for SIF declined to 1.7 (95 percent CI, 0.89 to 3.4).

"In conclusion, we have demonstrated a strong association between SIF and CAD in middle-aged individuals with ," the authors write. "SIF partially reflects the influence of skin advanced glycation end products, skin markers of oxidative stress and , subject age, diabetes duration, long-term glycemic control, and renal disease, which are associated with increased CAD risk."

Several authors are employees of or disclosed to Vera Light Inc., which funded the study and manufactures the SCOUT DS used to determine SIF.

Explore further: BPA exposure possibly linked to future heart disease

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

BPA exposure possibly linked to future heart disease

February 29, 2012
(HealthDay) -- Healthy people exposed to higher levels of the controversial chemical bisphenol A (BPA), found in plastics, may be more likely to develop heart disease, according to a study published online Feb. 21 in Circulation.

Epicardial fat tissue thickness predicts coronary artery disease

August 3, 2012
(HealthDay) -- Asymptomatic patients with coronary artery disease (CAD) have significantly more epicardial adipose tissue (EAT) than those without CAD, with an average EAT thickness of 2.4 mm or higher predictive of significant ...

Nonsupportive family members sabotage diabetes self-Care

May 2, 2012
(HealthDay) -- Diabetes patients with nonsupportive family members are less adherent to their diabetes medication regimen and have worse glycemic control, according to a study published online April 26 in Diabetes Care.

Polycystic ovarian syndrome ups risk of type 2 diabetes

June 22, 2012
(HealthDay) -- Middle-aged women with polycystic ovary syndrome (PCOS) are at increased risk of developing type 2 diabetes, according to a prospective long-term study published online June 14 in Diabetes.

Recommended for you

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.