Treatment of heart attacks with APOSEC: further mechanism unravelled

August 28, 2012
Treatment of heart attacks with APOSEC: further mechanism unravelled

The protein concentrate APOSEC, obtained from white blood cells, when given intravenously 40 minutes after an acute myocardial infarction, largely prevents scarring of the cardiac muscle. These were the findings of Hendrik Jan Ankersmit, Head of the Christian Doppler Laboratory for Diagnosis and Regeneration in Cardiac and Thoracic Diseases at the MedUni Vienna, which were unveiled back in the autumn of 2011. A study by a team of researchers led by Ankersmit has now unravelled further mechanisms responsible for how APOSEC works.

A , due to inflammation and "sticking" of the incoming blood supply caused by platelets in the blood can lead to microvascular obstruction (MVO) in the tissue of the affected organ. In ischaemic conditions (such as myocardial infarctions, strokes, etc.), an additional drug treatment that combines the effects of vasodilation, platelet aggregation inhibition and immunomodulation would be ideal.

 "Through fundamental research, we have demonstrated that APOSEC triggers several of these protective mechanisms at once. APOSEC contains, among others, nitrogen monoxide (NO), which is responsible for the vasodilating and platelet aggregation inhibiting effect after an . In collaboration with the working groups led by Prof. Mariann Gyöngyösi (Cardiology, MedUni Vienna) and Prof. Ivo Volf (Medical Physiology, MedUni Vienna), we have been able to demonstrate in large animal experiments that ECG changes in animals treated with APOSEC resolved and the signs of MVO were prevented."

APOSEC is a product containing soluble proteins that are excreted by after they are irradiated. The recovery of white as 'bio-reactors' is simple and can be compared in terms of effort to a regular blood donation. The product can be produced in advance and is easily available if the worst happens. A GMP facility is currently being set up in collaboration with the Red Cross's Blood Donation Centre in Linz (Dr. Christian Gabriel) to manufacture this "biological" under good manufacturing practice (GMP) conditions.

As part of his PhD thesis, Dr. Konrad Hoetzenecker from the Department of Thoracic Surgery was also able to demonstrate that APOSEC has an immunosuppressive effect in an experimental inflammation model. Working with Prof. Urs Eriksson from the University of Zürich, it was possible to demonstrate that CD4-positive T cells are forced under the influence of Caspase-8 to undergo programmed cell death (apoptosis). This explains a further fundamental scientific aspect of the effect of APOSEC.

Explore further: Promising and perilous? The ambivalent role of the CXCL12/ CXCR4 axis in heart repair

More information: "Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascluar obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation." K. Hoetzenecker, et al. Basic Res Cardiol (2012) 107:292; Article DOI: 10.1007/s00395-012-0292-2

Related Stories

Promising and perilous? The ambivalent role of the CXCL12/ CXCR4 axis in heart repair

November 30, 2011
The chemokine CXCL12 acts as a chemical signal which mobilizes hematopoietic and other types of stem cells to leave the bone marrow and enter the circulation. Secretion of CXCL12 also guides these cells to sites at which ...

Diseased hearts to heal themselves in future

November 11, 2011
Cellular reversion processes arise in diseases of the heart muscle, for example myocardial infarction and cardiomyopathy, which limit the fatal consequences for the organ. Scientists from the Max Planck Institute for Heart ...

Hormone reduces risk of heart failure from chemotherapy

August 4, 2011
Recent studies have shown that the heart contains cardiac stem cells that can contribute to regeneration and healing during disease and aging. However, little is known about the molecules and pathways that regulate these ...

One cause of fatty deposits in the hearts of diabetes patients settled

April 16, 2012
The impaired substrate metabolism of diabetes patients is often expressed in an increase in fatty deposits in the cells of the heart muscle. Until now, the exact cause of this was unknown. Now, Austrian researchers at the ...

Recommended for you

Metabolism switch signals end for healing hearts

September 19, 2017
Researchers have identified the process that shuts down the human heart's ability to heal itself, and are now searching for a drug to reverse it.

Beta blockers not needed after heart attack if other medications taken

September 18, 2017
A new study from the University of North Carolina at Chapel Hill finds beta blockers are not needed after a heart attack if heart-attack survivors are taking ACE inhibitors and statins. The study is the first to challenge ...

Which single behavior best prevents high blood pressure?

September 15, 2017
(HealthDay)—You probably already know that certain healthy lifestyle behaviors can reduce your risk of developing high blood pressure, but is any one behavior more important than the others?

RESPECT trial shows closing a small hole in heart may protect against recurrent stroke

September 13, 2017
A device used to close a small hole in the heart may benefit certain stroke patients by providing an extra layer of protection for those facing years of ongoing stroke risk, according to the results of a large clinical trial ...

Study shows so-called 'healthy obesity' is harmful to cardiovascular health

September 11, 2017
Clinicians are being warned not to ignore the increased cardiovascular health risks of those who are classed as either 'healthy obese' or deemed to be 'normal weight' but have metabolic abnormalities such as diabetes.

Statins reduce deaths from heart disease by 28 percent in men with high LDL levels, says longest ever study

September 6, 2017
Previous research has shown the benefit of statins for reducing high cholesterol and heart disease risk amongst different patient populations. However, until now there has been no conclusive evidence from trials for current ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.