Carefully scheduled high-fat diet resets metabolism and prevents obesity

September 12, 2012
Prof. Oren Froy of the Hebrew University’s Robert H. Smith Faculty of Agriculture, Food and Environment (Photo: Sasson Tiram)

(Medical Xpress)—New research from the Hebrew University of Jerusalem shows that a carefully scheduled high-fat diet can lead to a reduction in body weight and a unique metabolism in which ingested fats are not stored, but rather used for energy at times when no food is available.

The research was conducted by Prof. Oren Froy along with Prof. Zecharia Madar, research student Yoni Genzer and research fellow Dr. Hadas Sherman at the Institute of Biochemistry, Food Science and Nutrition, at the Hebrew University's Robert H. Smith Faculty of Agriculture, Food and Environment. The results were published in FASEB Journal under the title Timed high-fat resets circadian and prevents .

Previous research has established that disrupting ' daily rhythms, or feeding them a high-fat diet, disrupts metabolism and leads to obesity. The researchers wanted to determine the effect of combining a high-fat diet with long-term feeding on a fixed schedule. They hypothesized that careful scheduling of meals would regulate the and reduce the effects of a high-fat diet that, under normal circumstances, would lead to obesity.

For 18 weeks they fed a group of a high-fat diet on a fixed schedule (eating at the same time and for the same length of time every day). They compared these mice to three control groups: one that ate a low-fat diet on a fixed schedule, one that ate an unscheduled low-fat diet (in the quantity and frequency of its choosing), and one that ate an unscheduled high-fat diet.

All four groups of mice gained weight throughout the experiment, with a final body weight greater in the group that ate an unscheduled high-fat diet.

The mice on the scheduled high-fat diet had a lower final body weight than the mice eating an unscheduled high-fat diet. But surprisingly, the mice on the scheduled high-fat diet had a lower final than the mice that ate an unscheduled low-fat diet, even though both groups consumed the same amount of calories.

In addition, the mice on the scheduled high-fat diet exhibited a unique metabolic state in which the fats they ingested were not stored, but rather utilized for energy at times when no food was available, such as between meals.

According to Prof. Froy, "Our research shows that the timing of food consumption takes precedence over the amount of fat in the diet, leading to improved metabolism and helping to prevent obesity. Improving metabolism through the careful scheduling of meals, without limiting the content of the daily menu, could be used as a therapeutic tool to prevent obesity in humans."

Explore further: Molasses extract decreases obesity caused by a high-fat diet

More information: www.fasebj.org/content/early/2 … j.12-208868.abstract

Related Stories

Molasses extract decreases obesity caused by a high-fat diet

July 12, 2011
Experimental results to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, suggests that ...

High-fat diet may cause change in hypothalamus

September 11, 2012
(Medical Xpress)—A high fat diet may damage the part of the brain that controls appetite and energy expenditure which in turn dictates our weight.

Green tea helps mice keep off extra pounds

October 4, 2011
Green tea may slow down weight gain and serve as another tool in the fight against obesity, according to Penn State food scientists.

Voluntary exercise by animals prevents weight gain, despite high-fat diet

May 18, 2011
(Medical Xpress) -- University of Cincinnati (UC) researchers have found that animals on a high-fat diet can avoid weight gain if they exercise.

Recommended for you

'Obesity paradox' not found when measuring new cases of cardiovascular disease

December 7, 2017
Although obesity is a well-known risk factor for getting cardiovascular disease, a controversial body of research suggests that obesity may actually be associated with improved survival among people who have cardiovascular ...

Harmful effects of being overweight underestimated

December 1, 2017
The harmful effects of being overweight have been underestimated, according to a new study that analysed body mass index (BMI), health and mortality data in around 60,000 parents and their children, to establish how obesity ...

More than half of US children will have obesity as adults if current trends continue

November 29, 2017
If current trends in child obesity continue, more than 57% of today's children in the U.S. will have obesity at age 35, according to a new study from Harvard T.H. Chan School of Public Health.

Exercise alone does not lead to weight loss in women—in the medium term

November 23, 2017
Knowing whether or not exercise causes people to lose weight is tricky. When people take up exercise, they often restrict their diet – consciously or unconsciously – and this can mask the effects of the exercise. In our ...

Mindfulness training shows promise for maintaining weight loss

November 23, 2017
Can mindfulness training help overweight people shed pounds and keep them off? McGill University researchers surveyed the growing body of studies investigating that question, and came away encouraged.

Shaming overweight kids only makes things worse

November 20, 2017
(HealthDay)—Overweight kids who are shamed or stigmatized are more likely to binge eat or isolate themselves than to make positive changes such as losing weight, a leading pediatricians' group says.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.