Fructose and sugar substitutes alter gut microbiota

September 2, 2012
Fructose and sugar substitutes alter gut microbiota
High consumption of fructose, artificial sweeteners, and sugar alcohols affect host-gastrointestinal microbe interactions and may contribute to the development of metabolic disorders and obesity, according to research published in the September issue of Obesity Reviews.

(HealthDay)—High consumption of fructose, artificial sweeteners, and sugar alcohols affect host-gastrointestinal microbe interactions and may contribute to the development of metabolic disorders and obesity, according to research published in the September issue of Obesity Reviews.

Amanda N. Payne, Ph.D., of the Institute of Food, Nutrition, and Health in Zurich, and colleagues performed a comprehensive review of the literature to study how host-microbe interactions may contribute to metabolic disorders and obesity.

The researchers found that the reduced diversity in the fructose- and substitute sugar-laden Western diet caused a loss of diversity in the microflora, leading to the establishment of a "Western" gut microbiome. The adaptive metabolism generated additional metabolic activity for the host, which may have altered energy regulation and gut transit times, triggering enhancement of dietary energy extraction. These differences may be sensed by the immune system, leading to which later manifests as endotoxemia.

"The combination of these processes can undoubtedly contribute to development of many metabolic disorders associated with obesity," the authors write. "In conclusion, we suggest and prevention could be effectively achieved by promoting intestinal homeostasis through reintroduction of a balanced and diverse diet."

Explore further: Endotoxemia influenced by diet type

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Endotoxemia influenced by diet type

May 3, 2012
(HealthDay) -- A Western-style diet is associated with increased levels of endotoxin activity (endotoxemia), and a prudent-style diet (containing moderately greater amounts of omega-3 fatty acids, vitamin C, and vitamin E ...

Study offers insight to how fructose causes obesity, metabolic syndrome

February 27, 2012
A group of scientists from across the world have come together in a just-published study that provides new insights into how fructose causes obesity and metabolic syndrome, more commonly known as diabetes.

Sugar: Just how bad is it?

May 4, 2011
A couple of weeks ago, science writer Gary Taubes — author of the book “Why We Get Fat” — wrote an article for the New York Times magazine in which he analyzed the debate over whether sugar and high-fructose ...

Recommended for you

Kids with weight issues at high risk of emotional and behavioural problems

August 10, 2017
A new, in-depth study of New Zealand children and teenagers seeking help with weight issues has found their emotional health and wellbeing is, on average, markedly worse than that of children without weight issues.

Study finds 90 percent of American men overfat

July 24, 2017
Does your waist measure more than half your height?

Are sugary drink interventions changing people's behaviour?

July 19, 2017
An evaluation of efforts designed to reduce how many sugary drinks we consume shows some success in changing younger people's habits but warns they cannot be the only way to cut consumption.

Young adult obesity: A neglected, yet essential focus to reverse the obesity epidemic

July 18, 2017
The overall burden of the U.S. obesity epidemic continues to require new thinking. Prevention of obesity in young adults, while largely ignored as a target for prevention and study, will be critical to reversing the epidemic, ...

Weight gain from early to middle adulthood may increase risk of major chronic diseases

July 18, 2017
Cumulative weight gain over the course of early and middle adulthood may increase health risks later in life, according to a new study led by researchers from Harvard T.H. Chan School of Public Health. They found that, compared ...

Study finds children carry implicit bias towards peers who are overweight

June 23, 2017
Even children as young as 9 years old can carry a prejudice against their peers who are overweight, according to a new study led by Duke Health researchers. They might not even realize they feel this way.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.