Fructose and sugar substitutes alter gut microbiota

Fructose and sugar substitutes alter gut microbiota
High consumption of fructose, artificial sweeteners, and sugar alcohols affect host-gastrointestinal microbe interactions and may contribute to the development of metabolic disorders and obesity, according to research published in the September issue of Obesity Reviews.
(HealthDay)—High consumption of fructose, artificial sweeteners, and sugar alcohols affect host-gastrointestinal microbe interactions and may contribute to the development of metabolic disorders and obesity, according to research published in the September issue of Obesity Reviews.

Amanda N. Payne, Ph.D., of the Institute of Food, Nutrition, and Health in Zurich, and colleagues performed a comprehensive review of the literature to study how host-microbe interactions may contribute to metabolic disorders and obesity.

The researchers found that the reduced diversity in the fructose- and substitute sugar-laden Western diet caused a loss of diversity in the microflora, leading to the establishment of a "Western" gut microbiome. The adaptive metabolism generated additional metabolic activity for the host, which may have altered energy regulation and gut transit times, triggering enhancement of dietary energy extraction. These differences may be sensed by the immune system, leading to which later manifests as endotoxemia.

"The combination of these processes can undoubtedly contribute to development of many metabolic disorders associated with obesity," the authors write. "In conclusion, we suggest and prevention could be effectively achieved by promoting intestinal homeostasis through reintroduction of a balanced and diverse diet."


Explore further

Endotoxemia influenced by diet type

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Obesity Reviews

Copyright © 2012 HealthDay. All rights reserved.

Citation: Fructose and sugar substitutes alter gut microbiota (2012, September 2) retrieved 18 April 2019 from https://medicalxpress.com/news/2012-09-fructose-sugar-substitutes-gut-microbiota.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more