Genetic research addresses fatalities due to sepsis

September 17, 2012
Genetic research addresses fatalities due to sepsis
Credit: Thinkstock

The genetics of a patient affects the extent of septic shock development and response to therapy. European researchers have identified genes related to sepsis in a study group of more than 2,500 patients in Europe.

Septic shock is a condition that occurs as a result of severe infection to cause a systemic inflammatory response. Fatality from sepsis is high and mainly affects children, the elderly and those with a compromised immune system.

The 'Genetics of sepsis in Europe' (Genosept) project aimed to raise clinical awareness of how a patient's genes may affect important variables like response to treatment and possibility of fatal outcome. To achieve this goal, project scientists defined novel linked to the condition using expression studies. The identified genes were then analysed in relation to predisposition to sepsis-related mortality in European intensive care units.

Genosept scientists have established a system whereby future data can be recorded and therefore pooled in a database for further analysis. An electronic case report form (eCRF) provides details of each patient. Each eCRF is verified for quality and information content.

Most important for genotyping was the identification and evaluation of relevant candidate genes and their markers related to sepsis. Project researchers also developed processes and systems for blood sampling and genotyping tests.

Statistical analysis of the data linked the genetic variants identified with probability of mortality. Furthermore, the analysis pointed to associations between patient genes and phenotype related to sepsis outcomes.

Genosept has built a bridge between genomics and intensive care clinicians involved in this often fatal condition. Application of data means that expensive treatments for may be focused on high-risk patients. Standardisation of protocols also may be translated into the reduction of sepsis-related mortality.

Explore further: Early identification and treatment of septic shock to save lives

Related Stories

Early identification and treatment of septic shock to save lives

June 1, 2012
(Medical Xpress) -- Recognition of severe septic shock early and starting a patient on an effective antibiotic treatment immediately is critical to saving lives, according to an editorial by two Virginia Commonwealth University ...

Combination antibiotic treatment does not result in less organ failure in adults with severe sepsis

May 21, 2012
Frank M. Brunkhorst, M.D., of Friedrich-Schiller University, Jena, Germany, and colleagues conducted a study to compare the effect of the antibiotics moxifloxacin and meropenem with the effect of meropenem monotherapy on ...

Recommended for you

Scientists find key to regenerating blood vessels

November 23, 2017
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The ...

Surprising roles for muscle in tissue regeneration, study finds

November 22, 2017
A team of researchers at Whitehead has illuminated an important role for different subtypes of muscle cells in orchestrating the process of tissue regeneration. In a paper published in the November 22 issue of Nature, they ...

Study reveals new mechanisms of cell death in neurodegenerative disorders

November 22, 2017
Researchers at King's College London have discovered new mechanisms of cell death, which may be involved in debilitating neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

How rogue immune cells cross the blood-brain barrier to cause multiple sclerosis

November 21, 2017
Drug designers working on therapeutics against multiple sclerosis should focus on blocking two distinct ways rogue immune cells attack healthy neurons, according to a new study in the journal Cell Reports.

New simple test could help cystic fibrosis patients find best treatment

November 21, 2017
Several cutting-edge treatments have become available in recent years to correct the debilitating chronic lung congestion associated with cystic fibrosis. While the new drugs are life-changing for some patients, they do not ...

Researchers discover key signaling protein for muscle growth

November 20, 2017
Researchers at the University of Louisville have discovered the importance of a well-known protein, myeloid differentiation primary response gene 88 (MyD88), in the development and regeneration of muscles. Ashok Kumar, Ph.D., ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.