Long-term finasteride doesn't impair quality of life

September 13, 2012
Long-term finasteride doesn't impair quality of life
Taking finasteride to prevent prostate cancer does not negatively affect the physical function, mental health, or vitality domains of health-related quality of life, according to a study published online Sept. 12 in the Journal of the National Cancer Institute.

(HealthDay)—Taking finasteride to prevent prostate cancer does not negatively affect the physical function, mental health, or vitality domains of health-related quality of life, according to a study published online Sept. 12 in the Journal of the National Cancer Institute.

Carol M. Moinpour, Ph.D., from the Fred Hutchinson Cancer Research Center in Seattle, and colleagues examined the effect of finasteride on quality of life using data from questionnaires completed by Trial participants, who were randomized to finasteride or placebo for prevention of prostate cancer. Questionnaires were completed at enrollment (three months before randomization), six months after randomization, and annually for seven years. Three health-related quality-of-life domains were measured using the Health Survey Short Form 36: Physical Functioning, Mental Health, and Vitality scales.

The researchers found that finasteride had minor effects on physical function, accounting for less than a one-point difference over time in physical functioning scores. There were significant negative effects on physical function for comorbidities (including , leg pain, and diabetes), current smoking, and time on study. There were no significant effects of finasteride on mental health and vitality at any of the three time points, either in the mixed-effects analyses or in the cross-sectional analysis.

"In conclusion, taking finasteride for seven years did not appear to harm general aspects of health-related quality of life," the authors write.

Merck Inc. provided the drug and placebo used in the study.

Explore further: Hair loss drug shows long-term sexual side effects

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Hair loss drug shows long-term sexual side effects

July 23, 2012
(HealthDay) -- For men with finasteride-associated side effects, sexual dysfunction may persist for months or years, even after discontinuation of the drug, according to a study published online July 12 in The Journal of ...

Recommended for you

Drug suppresses spread of breast cancer caused by stem-like cells

December 12, 2017
Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, ...

MRI scans predict patients' ability to fight the spread of cancer

December 12, 2017
A simple, non-invasive procedure that can indicate how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy has been developed by researchers in Liverpool.

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

Insights on how SHARPIN promotes cancer progression

December 11, 2017
Researchers at Sanford Burnham Prebys Medical Discovery (SBP) and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex ...

Glioblastoma survival mechanism reveals new therapeutic target

December 11, 2017
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation ...

Liver cancer: Lipid synthesis promotes tumor formation

December 11, 2017
Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.