New anti-tumor cell therapy strategies are more effective

October 25, 2012, Mary Ann Liebert, Inc./Genetic Engineering News

Targeted T-cells can seek out and destroy tumor cells that carry specific antigen markers. Two novel anti-tumor therapies that take advantage of this T-cell response are described in articles published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available free on the Human Gene Therapy website.

Richard Morgan and colleagues from the (NCI), National Institutes of Health (NIH), Bethesda, MD, and Duke University Medical Center, Durham, NC, used engineered T-cells to attack glioma stem cells, which are one of the cell types present in glioblastoma, an aggressive and fatal type of brain cancer. There is no curative treatment for glioblastoma, and patients usually live less than two years from diagnosis. In the article "Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma," the authors describe how targeting tumor stem cells, in combination with traditional therapies aimed at killing other types of glioma , could improve the effectiveness of treatment and reduce tumor recurrence.

In a related article, Karen Kaluza and coauthors, Mayo Clinic, Rochester, MN, conducted a study using T-cells capable of recognizing two different antigens simultaneously and showed that this dual targeting strategy could be more effective at clearing tumor cells and reducing the risk of "tumor escape" and cancer recurrence. In "Adoptive Transfer of Cytotoxic Targeting Two Different Antigens Limits Antigen Loss and Tumor Escape," the authors conclude that T-cell therapies targeting two or more antigens will have significant added value compared to single-antigen therapies.

"These studies represent important advances in the development of novel treatments for cancer that combine the power of gene transfer and ," says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Explore further: New universal platform for cancer immunotherapy developed

Related Stories

New universal platform for cancer immunotherapy developed

March 5, 2012
(Medical Xpress) -- Researchers from the Perelman School of Medicine at the University of Pennsylvania report this month in Cancer Research a universal approach to personalized cancer therapy based on T cells. It is the first ...

Metabolic state of brain cancer stem cells significantly different than the cancer cells they create

September 6, 2011
The metabolic state of glioma stem cells, which give rise to deadly glioblastomas, is significantly different from that of the brain cancer cells to which they give birth, a factor which helps those stem cells avoid treatment ...

How immune cells destroy cancer cells: Researchers elucidate mechanism

January 17, 2012
In the treatment of large tumors, how effective is adoptive T cell therapy in comparison to drug-based cancer treatment? To answer this question, Dr. Kathleen Anders and Professor Thomas Blankenstein of the Max Delbrück ...

Cancer stem cell vaccine in development shows antitumor effect

April 2, 2012
Scientists may have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells, according to a study published in Cancer Research, a journal of the American Association ...

Recommended for you

Researchers identify a protein that keeps metastatic breast cancer cells dormant

January 23, 2018
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light ...

Scientists block the siren call of two aggressive cancers

January 23, 2018
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

Workouts may boost life span after breast cancer

January 22, 2018
(HealthDay)—Longer survival after breast cancer may be as simple as staying fit, new research shows.

Cancer patients who tell their life story find more peace, less depression

January 22, 2018
Fifteen years ago, University of Wisconsin–Madison researcher Meg Wise began interviewing cancer patients nearing the end of life about how they were living with their diagnosis. She was surprised to find that many asked ...

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.