Gene signature validated for oral cancer metastases

October 14, 2012
Gene signature validated for oral cancer metastases
A multigene signature effectively predicts the presence of lymph node metastases in squamous cell carcinoma of the oral cavity and oropharynx, according to a study published online Oct. 8 in the Journal of Clinical Oncology.

(HealthDay)—A multigene signature effectively predicts the presence of lymph node metastases in squamous cell carcinoma of the oral cavity (OSCC) and oropharynx (OPSCC), according to a study published online Oct. 8 in the Journal of Clinical Oncology.

Sander R. van Hooff, from the University Medical Center Utrecht in the Netherlands, and colleagues used a diagnostic DNA microarray to evaluate a previously reported multigene signature for distinguishing metastasizing from non-metastasizing (N0) OSCC and OPSCC in 222 patients from all head and neck oncology centers in the Netherlands.

The researchers found that the negative predictive value was 72 percent for the diagnostic signature in the entire validation cohort. In a subset of early-stage (cT1 to T2N0) OSCC (101 patients), the signature performed well, with a negative predictive value of 89 percent.

"Combining current with the expression signature would decrease the rate of undetected nodal metastases from 28 to 11 percent in early-stage OSCC. This should be sufficient to enable clinicians to refrain from elective neck treatment," the authors write. "A new clinical decision model that incorporates the expression signature is therefore proposed for testing in a prospective study, which could substantially improve treatment for this group of patients."

One author disclosed to the diagnostic company Agendia.

Explore further: Gene signature predicts oral cancer recurrence

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Gene signature predicts oral cancer recurrence

October 11, 2011
Oral Squamous Cell Carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers. It is one of the leading causes of cancer death - largely due to the failure of current histological procedures in predicting ...

Researchers validate molecular signature to predict radiation therapy benefit

August 16, 2012
Researchers at Moffitt Cancer Center, working with colleagues in Sweden, the Netherlands and Puerto Rico, have validated a radiosensitivity molecular signature that can lead to better radiation therapy decisions for treating ...

Study discovers gene signature that predicts prostate cancer survival

October 10, 2012
Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October ...

Researchers find malignancy-risk gene signature for early-stage non-small cell lung cancer

January 6, 2012
A malignancy-risk gene signature developed for breast cancer has been found to have predictive and prognostic value for patients with early stage non-small cell lung cancer. The advancement was made by researchers at Moffitt ...

Recommended for you

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Researchers develop swallowable test to detect pre-cancerous Barrett's esophagus

January 17, 2018
Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise ...

Scientists zoom in to watch DNA code being read

January 17, 2018
Scientists have unveiled incredible images of how the DNA code is read and interpreted—revealing new detail about one of the fundamental processes of life.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.