Researcher's surprising finding could lead to glanders vaccine

October 19, 2012
Results from this western blot analysis suggest that B. thailandensis ATPK01 (lane 5) contains immunogens that would generate protective immunity against B. mallei infection.

(Medical Xpress)—Apichai Tuanyok dedicated several years to working on a bacterial pathogen in Canada, but his breakthrough occurred in Flagstaff with an unexpected finding on a routine lab report.

Although the Tuanyok is investigating at Northern Arizona University is closely related to, but not the same, as the one he had researched in Canada, the results felt like a payoff for all the effort.

"I emailed many people that day," Tuanyok said, recalling his excitement at the lab report filed by his graduate student. What Tuanyok wrote in the email was that he possibly had found a vaccine target for glanders, a severe infectious disease that is usually limited to horses and donkeys but has potential as a biowarfare agent.  

Follow-up tests at NAU's Center for and Genomics (MGGen), where Tuanyok is an assistant research professor of biological sciences, have convinced Tuanyok that "we have the right target, but we have to identify further what bacterial species would be a good candidate" for an effective vaccine.

What Tuanyok found was that a common known as ATPK 1 plays a role in generating against glanders infection, with a 70 percent survival rate among infected .

Glanders, caused by the bacterium Burkholderia mallei, occurs in several countries in the Middle East, Mediterranean and South America. Human infection is uncommon but when it occurs, the bacterium is highly antibiotic resistant. No vaccine currently exists.

The Department of Defense has taken an interest because the bacterium, in aerosolized form, could be used as a bioweapon. During the , it is believed that Germany used methods to spread glanders intentionally, infecting Russian horses and mules used by the military. It was also used by the Japanese in .

Tuanyok is working on a manuscript with Paul Keim, NAU Regents' professor and director of MGGen, to describe the research and hopefully generate more funding.

It was Keim, in fact, who brought Tuanyok to the MGGen lab based on his work with melioidosis, a tropical disease that claims thousands of lives each year in Tuanyok's native Thailand. The bacterium behind that disease, Burkholderia pseudomallei, was still Tuanyok's focus when he first arrived at NAU in 2006. He may yet return to it.

"The vaccine we're working on may not be used for another disease," Tuanyok said, "but I have another idea for melioidosis and I may be able to do some work in parallel."

Explore further: Anthrax capsule vaccine protects monkeys from lethal infection

Related Stories

Anthrax capsule vaccine protects monkeys from lethal infection

January 12, 2012
a naturally occurring component of the bacterium that causes the disease—protected monkeys from lethal anthrax infection, according to U.S. Army scientists. The study, which appears in the Jan. 20th print edition of ...

Recommended for you

Google searches can be used to track dengue in underdeveloped countries

July 20, 2017
An analytical tool that combines Google search data with government-provided clinical data can quickly and accurately track dengue fever in less-developed countries, according to new research published in PLOS Computational ...

MRSA emerged years before methicillin was even discovered

July 19, 2017
Methicillin resistant Staphylococcus aureus (MRSA) emerged long before the introduction of the antibiotic methicillin into clinical practice, according to a study published in the open access journal Genome Biology. It was ...

New test distinguishes Zika from similar viral infections

July 18, 2017
A new test is the best-to-date in differentiating Zika virus infections from infections caused by similar viruses. The antibody-based assay, developed by researchers at UC Berkeley and Humabs BioMed, a private biotechnology ...

'Superbugs' study reveals complex picture of E. coli bloodstream infections

July 18, 2017
The first large-scale genetic study of Escherichia coli (E. coli) cultured from patients with bloodstream infections in England showed that drug resistant 'superbugs' are not always out-competing other strains. Research by ...

Ebola virus can persist in monkeys that survived disease, even after symptoms disappear

July 17, 2017
Ebola virus infection can be detected in rhesus monkeys that survive the disease and no longer show symptoms, according to research published by Army scientists in today's online edition of the journal Nature Microbiology. ...

Mountain gorillas have herpes virus similar to that found in humans

July 13, 2017
Scientists from the University of California, Davis, have detected a herpes virus in wild mountain gorillas that is very similar to the Epstein-Barr virus in humans, according to a study published today in the journal Scientific ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.