Study finds green tea reduces inflammation, may inhibit prostate cancer tumor growth

October 19, 2012

Men with prostate cancer who consumed green tea prior to undergoing prostatectomy had reductions in markers of inflammation, according to data presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, held here Oct. 16-19, 2012.

"Our study showed that drinking six cups of affected biomarkers in prostate tissue at the time of surgery," said Susanne M. Henning, Ph.D., R.D., adjunct professor at the David Geffen School of Medicine at the University of California Los Angeles. "This research offers new insights into the mechanisms by which green may reduce the risk for by opposing processes such as inflammation, which are associated with prostate cancer growth."

Prior epidemiological data have been inconclusive about the relationship between green tea and prostate cancer. However, one recent intervention study conducted in Italy revealed that men with a precursor to prostate cancer called prostatic intraepithelial neoplasia who consumed a green tea extract reduced their risk for progression to prostate cancer.

Henning and colleagues examined potential mechanisms by which green tea may have beneficial effects among 67 men with prostate cancer scheduled to undergo prostatectomy. The researchers randomly assigned the men to either six cups of brewed green tea or water daily for three to eight weeks, depending on the timing of their surgery. They collected blood and urine samples before and after the green tea or and collected prostate tissue following the pathology exam.

The data showed that serum prostate-specific antigen (PSA) concentrations were significantly lower at the end of the study compared with baseline levels in men consuming green tea. In addition, PSA was lower in men assigned to green tea consumption compared with the control group at the end of the study.

Further, immunostaining analysis revealed that nuclear factor kappa B, a marker of inflammation, was significantly reduced in those men assigned to green tea compared with those in the control group. A urinary marker of oxidative DNA damage was significantly decreased in urine from men consuming green tea compared with controls.

The researchers found no differences in markers of tumor cell proliferation between the two treatment groups.

Henning and her colleagues are further evaluating the association between green tea and prostate cancer by trying to enhance its activity. Currently, they are exploring the possibility of combining green tea with other natural products in mouse studies.  

Explore further: Tea drinkers may be at greater risk of prostate cancer: study

Related Stories

Tea drinkers may be at greater risk of prostate cancer: study

June 19, 2012
(Medical Xpress) -- Men who are heavy tea drinkers may be more likely to develop prostate cancer, according to research from scientists at the University of Glasgow which is published in the journal Nutrition and Cancer.

Mechanisms of action for green tea extract in breast cancer prevention identified

October 18, 2012
An oral green tea extract, Polyphenon E, appears to inhibit vascular endothelial growth factor and hepatocyte growth factor, both of which promote tumor cell growth, migration and invasion.

Recommended for you

Alternative splicing, an important mechanism for cancer

September 22, 2017
Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death. Thanks to the advances ...

'Labyrinth' chip could help monitor aggressive cancer stem cells

September 21, 2017
Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. ...

Drug combination may improve impact of immunotherapy in head and neck cancer

September 21, 2017
Checkpoint inhibitor-based immunotherapy has been shown to be very effective in recurrent and metastatic head and neck cancer but only in a minority of patients. University of California San Diego School of Medicine researchers ...

Whole food diet may help prevent colon cancer, other chronic conditions

September 21, 2017
A diet that includes plenty of colorful vegetables and fruits may contain compounds that can stop colon cancer and inflammatory bowel diseases in pigs, according to an international team of researchers. Understanding how ...

New kinase detection method helps identify targets for developing cancer drugs

September 21, 2017
Purdue University researchers have developed a high-throughput method for matching kinases to the proteins they phosphorylate, speeding the ability to identify multiple potential cancer drug targets.

Poliovirus therapy induces immune responses against cancer

September 20, 2017
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.