HIV helps explain rise of anal cancer in US males

October 6, 2012, Journal of the National Cancer Institute

The increase in anal cancer incidence in the U.S. between 1980 and 2005 was greatly influenced by HIV infections in males, but not females, according to a study published October 5 in the Journal of the National Cancer Institute.

Anal cancer in the U.S. is rare, with an estimated 6,230 cases in 2012, but incidence has been steadily increasing in the general population since 1940. is significantly associated with an increase in anal , and anal cancer is the fourth most common cancer found in HIV-infected people. However, it has been unclear the degree to which anal cancer cases occurring among people with HIV has affected anal cancer incidence in the general population.

In order to determine the impact of HIV on anal cancer incidence in the U.S., Meredith S. Shiels, Ph.D., M.H.S., of the National Cancer Institute and colleagues looked at data from the HIV/AIDS Cancer Match Study—specifically the number of people with anal cancer with and without HIV between 1980 and 2005 in 17 U.S. states and metropolitan areas.

The researchers found that of the 20,533 anal cancer cases between 1980 and 2005, an estimated 1,665 individuals were infected with HIV. In 2001-2005, the most recent time period examined, 1.2% of women with anal cancer and 28.4% of men with anal cancer were HIV-positive. During 1980-2005, HIV infection did not have an impact on the increasing anal cancer incidence rates among women, but HIV had a strong impact on the increasing anal cancer incidence rates among men. "A large proportion of U.S. males with anal cancer in recent years were HIV-infected," the authors write, adding that, "Measures that would effectively prevent anal cancer in HIV-infected males could markedly reduce anal at the ."

Explore further: HIV raises anal cancer risk in women, study says

More information: DOI:10.1093/jnci/djs371

Related Stories

HIV raises anal cancer risk in women, study says

April 16, 2012
(HealthDay) -- Women with HIV are at increased risk for anal cancer, a new study finds.

Most anal lesions don't cause cancer in men, research shows

March 23, 2012
(HealthDay) -- Anal human papillomavirus (HPV) infection and precancerous lesions are common among gay and bisexual men, but most of these cases will not progress to anal cancer, a new analysis of earlier research shows.

Cervical vaccine also protects against anal cancer risk

August 23, 2011
A vaccine routinely used to shield against cervical cancer caused by the human papillomavirus also reduces women's risk of anal cancer, a study published by the journal The Lancet Oncology on Tuesday says.

Cancer burden shifts for people with HIV/AIDS

April 11, 2011
The number of cancers and the types of cancers among people living with AIDS in the U.S. have changed dramatically during the 15-year period from 1991-2005, according to an article published online April 11th in the Journal ...

Recommended for you

HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection

January 18, 2018
A first-of-its-kind study has found that the genetic diversity of human immunodeficiency virus type 1 (HIV-1) is higher in the vaginal tract than in the blood stream during early infection. This finding, published in PLOS ...

War in Ukraine has escalated HIV spread in the country: study

January 15, 2018
Conflict in Ukraine has increased the risk of HIV outbreaks throughout the country as displaced HIV-infected people move from war-affected regions to areas with higher risk of transmission, according to analysis by scientists.

Researchers offer new model for uncovering true HIV mortality rates in Zambia

January 12, 2018
A new study that seeks to better ascertain HIV mortality rates in Zambia could provide a model for improved national and regional surveillance approaches, and ultimately, more effective HIV treatment strategies.

New drug capsule may allow weekly HIV treatment

January 9, 2018
Researchers at MIT and Brigham and Women's Hospital have developed a capsule that can deliver a week's worth of HIV drugs in a single dose. This advance could make it much easier for patients to adhere to the strict schedule ...

New long-acting, less-toxic HIV drug suppresses virus in humanized mice

January 8, 2018
A team of Yale researchers tested a new chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose. In animal experiments, the compound proved to be a promising new candidate ...

Usage remains low for pill that can prevent HIV infection

January 8, 2018
From gritty neighborhoods in New York and Los Angeles to clinics in Kenya and Brazil, health workers are trying to popularize a pill that has proven highly effective in preventing HIV but which—in their view—remains woefully ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

freethinking
1 / 5 (1) Oct 07, 2012
How about this. During High School Sex education, they should teach that if you have homosexual sex, you increase significantly the odds of you getting Anal cancer, AIDS, and a whole bunch of other nasty sexual diseases and disorders.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.