Osteoporosis risk factors after the menopause

November 13, 2012, Inderscience Publishers

A preliminary study of 127 post-menopausal women on hormone replacement therapy in Portugal suggests that there are several risk factors associated with osteoporosis and bone fracture these include age, low bone mineral density, a sedentary lifestyle, coffee consumption and ovariectomy. Details are reported later this month in the International Journal of Medical Engineering and Informatics.

Osteoporosis is a disease of the skeleton commonly associated with low bone mass and is predominant in elderly, post-menopausal women. Elza Fonseca of the Polytechnic Institute of Bragança and colleagues there and at the Medical Imaging Centre in Porto, point out that osteoporosis was common in the group of Portuguese women studied. They discuss data from different geographic regions concerning this public health problem.

The team hoped to identify common factors and so underpin knowledge on this potentially debilitating and critical bone disease. The clinical relevance is that those with the condition are highly susceptible to , which can lead to pain, hospitalisation and disablement, particularly in the case of hip, spine and wrist fracture. Indeed, fractures linked to osteoporosis are unfortunately often linked to patient death.

Bone mass density as determined by dual energy X-ray (DEXA) has been used frequently to determine whether a particular patient is at increased risk of fracture, it also provides a quantitative marker for osteoporosis, which is defined as having BMD 2.5 standard deviations below average. Osteopenia, a precursor condition to osteoporosis, is marked by a BMD 1.0 to 2.5 below average.

The researchers point out that, controversy exists among experts regarding the value of BMD as a diagnostic criterion for osteoporosis. They explain that there is good evidence to support the cost-effectiveness and efficacy of early prescription of preventive drugs, but it is not clear at which point below the threshold this should be. Their new study on lifestyle and other risk factors should couple neatly with such discussions and allow more informed decisions to be made regarding the use.

Explore further: Experts recommend men at risk for osteoporosis undergo bone density testing

More information: "Bone fragility in postmenopausal women: a preliminary study" in Int. J.Medical Engineering and Informatics, 2012, 4, 387-397.

Related Stories

Experts recommend men at risk for osteoporosis undergo bone density testing

June 18, 2012
Osteoporosis in men causes significant morbidity and mortality. Today, the Endocrine Society released clinical practice guidelines (CPG) for management of this condition in men. "Osteoporosis in Men: An Endocrine Society ...

New study highlights what works in osteoporosis treatment

July 11, 2011
More patients are tested and treated for osteoporosis when fracture clinics have someone dedicated to screening for the bone disease, a new study has found.

Genes linked to osteoporosis, bone breaks

April 16, 2012
Researchers at The Institute for Aging Research at Hebrew SeniorLife, an affiliate of Harvard Medical School, have co-authored the largest meta-analysis of genome-wide association studies of osteoporosis as part of an international ...

Recommended for you

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

New study validates clotting risk factors in chronic kidney disease

January 17, 2018
In late 2017, researchers from Boston University School of Medicine (BUSM) discovered and published (Science Translational Medicine, (9) 417, Nov 2017) a potential treatment target to prevent chronic kidney disease (CKD) ...

Fresh approach to tuberculosis vaccine offers better protection

January 17, 2018
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.

Newly-discovered TB blood signal provides early warning for at-risk patients

January 17, 2018
Tuberculosis can be detected in people with HIV infection via a unique blood signal before symptoms appear, according to a new study by researchers from the Crick, Imperial College London and the University of Cape Town.

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.