U-shaped link for BMI at diagnosis with mortality in T2DM

November 16, 2012
U-shaped link for BMI at diagnosis with mortality in T2DM
For patients with type 2 diabetes mellitus, classification as normal weight or obese within a year of initial diabetes diagnosis correlates with significantly higher mortality, forming a U-shaped association between body mass index and mortality, according to a study published online Nov. 8 in Diabetes Care.

(HealthDay)—For patients with type 2 diabetes mellitus (T2DM), classification as normal weight or obese within a year of initial diabetes diagnosis correlates with significantly higher mortality, forming a U-shaped association between body mass index (BMI) and mortality, according to a study published online Nov. 8 in Diabetes Care.

Jennifer Logue, M.D., of the University of Glasgow in the United Kingdom, and colleagues used data from 106,640 patient records to describe the association between BMI recorded at the time of T2DM diagnosis and mortality.

During a mean follow-up of 4.7 years, the researchers found that the risk of death was significantly higher in patients with a BMI of 20 to <25 kg/m² and patients with a BMI ≥35 kg/m². For each 5-kg/m² increase in BMI above 30 kg/m², the risk of vascular mortality increased by 24 percent for men and 23 percent for women, but was reduced below this threshold. These results were generally similar after adjustment for glycated hemoglobin, year of diagnosis, lipid levels, blood pressure, and patient socioeconomic status.

"Further research is needed to investigate the mechanisms of obesity-related , potential mechanisms for increased mortality at lower BMI, and also the effect of weight loss interventions on morbidity and mortality in people with T2DM with differing levels of baseline BMI," the authors write.

Explore further: Obesity, overweight at diagnosis ups B-cell lymphoma prognosis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Obesity, overweight at diagnosis ups B-cell lymphoma prognosis

May 30, 2012
(HealthDay) -- For U.S. veterans with diffuse large B-cell lymphoma (DLBCL), being overweight or obese at time of diagnosis correlates with improved survival, according to a study published online May 29 in the Journal of ...

Long-term type 2 diabetes ups pancreatic cancer mortality

August 15, 2012
(HealthDay) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online ...

Lower all-Cause, cardio mortality in obese with RA

May 2, 2012
(HealthDay) -- Overweight and obese patients with rheumatoid arthritis (RA) have lower all-cause and cardiovascular mortality, but have substantially increased risks of comorbidities, medical costs, and reduced quality of ...

Body mass index associated with short-term mortality rates following surgery

November 21, 2011
Body Mass Index (BMI) appears to be associated with 30-day mortality risk following surgical procedures, and patients with a BMI of less than 23.1 appear to be at highest risk of death, according to a report published Online ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.