Obesity, overweight at diagnosis ups B-cell lymphoma prognosis

May 30, 2012
Obesity, overweight at diagnosis ups B-Cell lymphoma prognosis
For U.S. veterans with diffuse large B-cell lymphoma, being overweight or obese at time of diagnosis correlates with improved survival, according to a study published online May 29 in the Journal of Clinical Oncology.

(HealthDay) -- For U.S. veterans with diffuse large B-cell lymphoma (DLBCL), being overweight or obese at time of diagnosis correlates with improved survival, according to a study published online May 29 in the Journal of Clinical Oncology.

To investigate the association between (BMI) at diagnosis and overall survival, Kenneth R. Carson, M.D., from the St. Louis Veterans Affairs Medical Center, and colleagues conducted a involving 2,534 U.S. veterans diagnosed with DLBCL from 1998 to 2008.

The researchers found that the mean age at diagnosis was 68 years, and 64 percent of patients were overweight or obese. Compared with other BMI groups, obese patients were significantly younger, had significantly fewer B symptoms, and showed a trend toward lower-stage disease. Compared with normal-weight patients, Cox analysis showed decreased mortality for overweight and obese patients (hazard ratios, 0.73 and 0.68, respectively). Treatment during the rituximab era attenuated the but did not impact the association between BMI and survival. One year before diagnosis, disease-related weight loss occurred in 29 percent of patients with weight data, but Cox analysis based on BMI one year before diagnosis showed a persistent association between overweight/obesity and reduced mortality risk.

"Being overweight or obese at the time of DLBCL diagnosis is associated with improved overall survival," the authors write. "Understanding the mechanisms responsible for this association will require further study."

One author disclosed a financial relationship with Genentech.

Explore further: Physician's weight may influence obesity diagnosis and care

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Physician's weight may influence obesity diagnosis and care

January 26, 2012
A patient's body mass index (BMI) may not be the only factor at play when a physician diagnoses a patient as obese. According to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health, the diagnosis ...

Lower all-Cause, cardio mortality in obese with RA

May 2, 2012
(HealthDay) -- Overweight and obese patients with rheumatoid arthritis (RA) have lower all-cause and cardiovascular mortality, but have substantially increased risks of comorbidities, medical costs, and reduced quality of ...

Recommended for you

CAR-T immunotherapy may help blood cancer patients who don't respond to standard treatments

October 20, 2017
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers. Newly approved ...

Researchers pinpoint causes for spike in breast cancer genetic testing

October 20, 2017
A sharp rise in the number of women seeking BRCA genetic testing to evaluate their risk of developing breast cancer was driven by multiple factors, including celebrity endorsement, according to researchers at the University ...

Study shows how nerves drive prostate cancer

October 19, 2017
In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels ...

Gene circuit switches on inside cancer cells, triggers immune attack

October 19, 2017
Researchers at MIT have developed a synthetic gene circuit that triggers the body's immune system to attack cancers when it detects signs of the disease.

One to 10 mutations are needed to drive cancer, scientists find

October 19, 2017
For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumours across 29 cancer types. Researchers from the Wellcome Trust Sanger ...

Researchers target undruggable cancers

October 19, 2017
A new approach to targeting key cancer-linked proteins, thought to be 'undruggable," has been discovered through an alliance between industry and academia.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.