Adalimumab relieves hidradenitis suppurativa

December 18, 2012
Adalimumab relieves hidradenitis suppurativa
For patients with moderate-to-severe hidradenitis suppurativa, a chronic skin disease characterized by painful abscesses, nodules, and draining fistulas in the axilla and groin, treatment with once-weekly adalimumab is associated with improvements in pain and inflammation, according to a study published online Dec. 17 in the Annals of Internal Medicine.

(HealthDay)—For patients with moderate-to-severe hidradenitis suppurativa (HS), a chronic skin disease characterized by painful abscesses, nodules, and draining fistulas in the axilla and groin, treatment with once-weekly adalimumab is associated with improvements in pain and inflammation, according to a study published online Dec. 17 in the Annals of Internal Medicine.

Alexa B. Kimball, M.D., M.P.H., of Harvard Medical School in Boston, and colleagues conducted a parallel, randomized trial involving 154 adult patients with moderate-to-severe HS who did not respond to or who were intolerant of . Patients were allocated to receive placebo or 40 mg adalimumab every week or every other week (EOW) for 16 weeks. All patients were switched to EOW at the start of an open-label 36 week phase, while those who had a suboptimal response could switch to weekly dosing at that point.

After 16 weeks of treatment, the researchers found that a clinical response was achieved in 9.6 percent of those who received EOW adalimumab, 17.6 percent of those who received weekly adalimumab, and 3.9 percent of placebo-treated patients. Serious adverse events were reported in 5.8 percent of EOW, 7.8 percent of weekly, and 3.9 percent of placebo-treated patients. Compared with the placebo group, patients who received weekly adalimumab reported significantly higher improvements in outcomes and pain. Patients who switched from weekly to EOW adalimumab treatment showed a reduction in clinical response.

"This phase 2 dose-ranging study showed evidence of efficacy and tolerability of adalimumab in HS," the authors write. "Inflammation and pain were reduced, and impairment of health-related quality of life and increased."

The study was funded by , the manufacturer of ; several authors disclosed financial ties to Abbott.

Explore further: Immunogenicity strongly impacts response to adalimumab in RA

More information: Full Text (subscription or payment may be required)

Related Stories

Immunogenicity strongly impacts response to adalimumab in RA

December 13, 2012
(HealthDay)—For patients with rheumatoid arthritis (RA), long-term clinical outcomes are good with etanercept and adalimumab; but for adalimumab, treatment response is strongly dependent on the presence or absence of anti-adalimumab ...

Adalimumab is a promising therapy for children with Crohn's disease

August 6, 2012
Adalimumab (an anti-tumor necrosis factor [TNF] antibody) is effective in maintaining remission in certain pediatric patients with Crohn's disease, according to a new study in Gastroenterology, the official journal of the ...

Head-to-head study in RA shows that abatacept has comparable efficacy to adalimumab

June 7, 2012
Data from one of the few head-to-head trials in rheumatoid arthritis (RA) presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, demonstrates that at one year, 64.8% of patients receiving ...

Study compares effectiveness of psoriasis treatments

April 20, 2012
(HealthDay) -- The effectiveness of therapies for psoriasis is variable, and may be lower in real-world settings than in trial settings, according to a study published in the April issue of the Archives of Dermatology.

UVB preferred for treatment of moderate to severe psoriasis

February 24, 2012
(HealthDay) -- Ultraviolet B (UVB) is preferred by dermatologists for first-line treatment of moderate to severe psoriasis in both healthy male and female patients, according to a study published in the March issue of the ...

Reasons for discontinuation vary by psoriasis treatment

August 10, 2012
(HealthDay) -- The reasons for discontinuation of commonly used treatments for psoriasis vary by treatment, according to a study published online July 30 in the Journal of the American Academy of Dermatology.

Recommended for you

Chronic inflammation causes loss of muscle mass during aging

January 12, 2018
People start losing muscle mass at the age of 40—about some 10 percent of the total muscle mass for each 10-year period, which may lead to fall-related injuries, slowing metabolism and reduced quality of life. Today, very ...

Breathing exercises help asthma patients with quality of life

December 13, 2017
A study led by the University of Southampton has found that people who continue to get problems from their asthma, despite receiving standard treatment, experience an improved quality of life when they are taught breathing ...

Study highlights the need for research into prevention of inflammatory bowel disease

December 7, 2017
Countries in Africa, Asia, the Middle East and South America have seen a rise in incidence of inflammatory bowel disease as they have become increasingly industrialised and westernised, a new study has found.

Air pollution can increase asthma risk in adults, even at low levels

November 24, 2017
Living close to a busy road can be bad for your respiratory health if you are middle aged, new Australian research has found.

Evidence found of oral bacteria contributing to bowel disorders

October 20, 2017
(Medical Xpress)—An international team of researchers has found evidence that suggests certain types of oral bacteria may cause or exacerbate bowel disorders. In their paper published in the journal Science, the group describes ...

New compound discovered in fight against inflammatory disease

September 22, 2017
A 10-year study by University of Manchester scientists for a new chemical compound that is able to block a key component in inflammatory illness has ended in success.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.