NSAIDs exacerbate exercise-induced small intestinal injury

December 12, 2012
NSAIDs exacerbate exercise-induced small intestinal injury
Nonsteroidal anti-inflammatory drugs aggravate exercise-induced small intestinal injury in athletes, according to a study published in the December issue of Medicine & Science in Sports & Exercise.

(HealthDay)—Nonsteroidal anti-inflammatory drugs (NSAIDs) aggravate exercise-induced small intestinal injury in athletes, according to a study published in the December issue of Medicine & Science in Sports & Exercise.

Kim van Wijck, M.D., from the Maastricht University Medical Center in the Netherlands, and colleagues studied nine healthy, trained men under four conditions: 400 mg twice before cycling; cycling without ibuprofen; 400 mg ibuprofen twice at rest; and rest without ibuprofen intake. Plasma intestinal fatty acid binding protein (I-FABP) levels were used to assess small intestinal injury. Liquid chromatography and mass spectrometry were used to measure urinary excretion of orally ingested multi-sugar test probes to assess gastrointestinal permeability.

The researchers observed increased I-FABP levels with both ibuprofen consumption and cycling, indicative of small intestinal injury. Levels were highest after cycling with ibuprofen versus cycling without ibuprofen and rest with or without ibuprofen. Small intestinal permeability increased, particularly after with ibuprofen, indicative of gut barrier integrity loss. There was a significant correlation between the extent of intestinal injury and barrier dysfunction.

"The current study shows that, in healthy endurance athletes, NSAID consumption can aggravate exercise-induced small intestinal injury and induces loss of gut barrier function," the authors write. "We consider it of utmost importance to increase the awareness of athletes and trainers toward the potential negative effects of and recommend that the use of NSAIDs in the absence of a clear medical indication should be discouraged."

Explore further: Fetal NSAID exposure not tied to persistent pulmonary HTN

More information: Full Text

Related Stories

Fetal NSAID exposure not tied to persistent pulmonary HTN

December 3, 2012
(HealthDay)—There appears to be no association between persistent pulmonary hypertension of the newborn (PPHN) and gestational exposure to nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, according to ...

A study demonstrates that ibuprofen improves bone repair after surgery or a fracture

July 3, 2012
A study conducted at the University of Granada hasdemonstrated that ibuprofen ­–a non-steroidal anti-inflammatory drug (NSAID)­– has beneficial effects on bone repair after afracture or following bone ...

Recommended for you

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...

Team eradicates hepatitis C in 10 patients following lifesaving transplants from infected donors

April 30, 2017
Ten patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease. The findings point to new strategies for increasing ...

'bench to bedside to bench': Scientists call for closer basic-clinical collaborations

March 24, 2017
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX), National Human Genome Research ...

The ethics of tracking athletes' biometric data

January 18, 2017
(Medical Xpress)—Whether it is a FitBit or a heart rate monitor, biometric technologies have become household devices. Professional sports leagues use some of the most technologically advanced biodata tracking systems to ...

Financial ties between researchers and drug industry linked to positive trial results

January 18, 2017
Financial ties between researchers and companies that make the drugs they are studying are independently associated with positive trial results, suggesting bias in the evidence base, concludes a study published by The BMJ ...

Best of Last Year – The top Medical Xpress articles of 2016

December 23, 2016
(Medical Xpress)—It was a big year for research involving overall health issues, starting with a team led by researchers at the UNC School of Medicine and the National Institutes of Health who unearthed more evidence that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.