Effect of obesity gene variant influenced by age

January 31, 2013
Effect of obesity gene variant influenced by age
A genetic variant associated with obesity risk (FTO) has a greater effect on body mass index in young adults than older adults, according to a study published online Jan. 8 in Diabetes.

(HealthDay)—A genetic variant associated with obesity risk (FTO) has a greater effect on body mass index (BMI) in young adults than older adults, according to a study published online Jan. 8 in Diabetes.

Mariaelisa Graff, Ph.D., from the University of North Carolina at Chapel Hill, and colleagues analyzed the associations of five established obesity risk variants with BMI in 34,053 European Americans (18 to 100 years old) across four periods of adulthood, and by menopausal status in women and stratification by 50 years of age in men.

The researchers found that the association of the FTO (rs8050136) variant with BMI was heterogeneous across all four age ranges, with the largest effect observed in young adults (18 to 25 years old). This did not appear to be specifically related to menopausal status in women or the cut-off of 50 years of age in men. There was no observed heterogeneity in the association of the GNPDA2, MTCH2, TMEM18, and NEGR1 variants with BMI.

" to obesity may have greater effects on body weight in young compared with older adulthood for FTO, suggesting changes by age, generation, or secular trends," Graff and colleagues write.

Explore further: Fat gene variants linked to middle age memory decline

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Fat gene variants linked to middle age memory decline

November 8, 2012
(HealthDay)—For white middle-aged adults, there may be an association between variants in a gene associated with fat mass and obesity (FTO) and memory decline, according to research published online Nov. 7 in Neurology.

Excess weight in young adulthood predicts shorter lifespan

August 17, 2011
(Medical Xpress) -- Those 25-year-olds who are overweight now but think they will be fine as long as they lose weight eventually might need to reconsider. A study appearing online in the Journal of Adolescent Health finds ...

ECO: Behavioral treatment for obesity effective in children

May 14, 2012
(HealthDay) -- Behavioral treatment for obesity is much more effective for younger children than for adolescents, according to a study presented at the European Congress on Obesity, held from May 9 to 11 in Lyon, France.

Recommended for you

Diabetes can be tracked with our Google searches

July 26, 2017
The emergence of Type 2 Diabetes could be more effectively monitored using our Google searches—helping public health officials keep track of the disease and halt its spread—according to research by the University of Warwick.

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.