ERCC1 not effective for guiding therapeutic decisions

March 21, 2013
ERCC1 not effective for guiding therapeutic decisions
Currently available antibodies for the excision repair cross-complementation group 1 protein are not adequate for therapeutic decision-making regarding the potential efficacy of cisplatin-containing treatment in patients with non-small-cell lung cancer, according to a study published in the March 21 issue of the New England Journal of Medicine.

(HealthDay)—Currently available antibodies for the excision repair cross-complementation group 1 (ERCC1) protein are not adequate for therapeutic decision-making regarding the potential efficacy of cisplatin-containing treatment in patients with non-small-cell lung cancer, according to a study published the March 21 issue of the New England Journal of Medicine.

Luc Friboulet, Ph.D., from University of Paris, used the 8F1 antibody to measure the level of expression of ERCC1 protein using immunohistochemical analysis in a validation set of 499 patient samples obtained from two independent phase 3 trials.

The researchers were unable to validate the predictive effect of immunostaining for ERCC1 protein. They found discordance in staining for ERCC1 suggestive of a change in the performance of the 8F1 antibody since 2006, when an initial correlation between the absence of ERCC1 expression and platinum response was identified. None of the 16 antibodies could distinguish among the four ERCC1 protein isoforms. A protein capable of nucleotide excision repair and resistance was only produced by one isoform.

"Immunohistochemical analysis with the use of currently available ERCC1 did not specifically detect the unique functional ERCC1 isoform," the authors write.

Eli Lilly funded the study.

Explore further: Novel therapeutic targets identified for small cell lung cancer

More information: Full Text (subscription or payment may be required)

Related Stories

Novel therapeutic targets identified for small cell lung cancer

September 6, 2012
Newly discovered molecular differences between small cell lung cancer and nonsmall cell lung cancer have revealed PARP1 and EZH2 as potential therapeutic targets for patients with small cell lung cancer, according to the ...

Novel antibodies for combating Alzheimer's and Parkinson's disease

December 3, 2012
Antibodies developed by researchers at Rensselaer Polytechnic Institute are unusually effective at preventing the formation of toxic protein particles linked to Alzheimer's disease and Parkinson's disease, as well as Type ...

Cross-reactive antibodies vanquish H5N1 in preclinical study

March 20, 2012
The H5N1 influenza has proven extraordinarily deadly. More than 50 percent of the 500 cases that have been documented since the virus first emerged in 1997 have been fatal. Thus, H5N1 is viewed as a serious threat to world ...

Recommended for you

Poliovirus therapy induces immune responses against cancer

September 20, 2017
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells ...

Scientists restore tumor-fighting structure to mutated breast cancer proteins

September 20, 2017
Scientists at the Virginia Tech Carilion Research Institute have successfully determined the full architecture of the breast cancer susceptibility protein (BRCA1) for the first time. This three-dimensional information provides ...

Brain cancer growth halted by absence of protein, study finds

September 20, 2017
The growth of certain aggressive brain tumors can be halted by cutting off their access to a signaling molecule produced by the brain's nerve cells, according to a new study by researchers at the Stanford University School ...

Researchers identify new target, develop new drug for cancer therapies

September 20, 2017
Opening up a new pathway to fight cancer, researchers at the University of Pennsylvania have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to ...

New clinical trial explores combining immunotherapy and radiation for sarcoma patients

September 20, 2017
University of Maryland School of Medicine researchers are investigating a new approach to treat high-risk soft-tissue sarcomas by combining two immunotherapy drugs with radiation therapy to stimulate the immune system to ...

Targeted antibiotic use may help cure chronic myeloid leukaemia

September 19, 2017
The antibiotic tigecycline, when used in combination with current treatment, may hold the key to eradicating chronic myeloid leukaemia (CML) cells, according to new research.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.