Intensive glycemic control linked to highest weight gains

Intensive glycemic control linked to highest weight gains
Weight gain is higher in patients with type 2 diabetes mellitus who receive more intensive glycemic control treatment and is associated with a reduction of A1C from baseline, according to research published online Feb. 14 in Diabetes Care.
(HealthDay)—Weight gain is higher in patients with type 2 diabetes mellitus (T2DM) who receive more intensive glycemic control treatment and is associated with a reduction of A1C from baseline, according to research published online Feb. 14 in Diabetes Care.

Vivian Fonseca, M.D., of Tulane University's Health Sciences Center in New Orleans, and colleagues studied the determinants of weight gain in 8,929 patients with T2DM from the Action to Control Cardiovascular Risk in Diabetes trial who either participated in standard (4,504) or intensive glycemic control treatment arms (4,425).

The researchers found that patients in the intensive glycemia arm gained an average of 2.7 kg more than those in the standard arm (3.0 versus 0.3 kg). Independent factors associated with weight gain over the two-year treatment duration included younger age, male sex, Asian race, no smoking history, high A1C, baseline of 25 to 35 kg/m², high , baseline insulin use, and baseline metformin use. Overall, medication use was associated with less than 15 percent of the variability in weight change.

"Following randomization, the intensive group participants with the greatest reduction in A1C gained the most weight," the authors write. "Insulin and TZD [thiazolidinedione] use was associated with the greatest weight gain. Nevertheless, appreciation of these characteristics may help develop strategies to prevent weight gain when initiating intensive glycemic control in the future."


Explore further

Post-pregnancy deterioration in glycemic control in T1DM

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Health News Copyright © 2013 HealthDay. All rights reserved.

Citation: Intensive glycemic control linked to highest weight gains (2013, March 21) retrieved 25 June 2019 from https://medicalxpress.com/news/2013-03-intensive-glycemic-linked-highest-weight.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more