New methods help to improve attachment of an implant to bone

March 13, 2013
The cytoskeleton became activated on a three-dimensional (B) surface. Activation is indicated by the red (ERK) and green (ROCK) staining of protein kinases. Staining of the nucleus is blue.

Replacement of prostheses is unpleasant to the patient and expensive to society. Replacement of failed hip prostheses gives rise to an expenditure of about 10 million euros yearly in Finland. A usual reason for the need to change a prosthesis is its becoming detached from bone. A recent doctoral dissertation at Aalto University has come across several methods with which the adhesion of implants to bone can be improved.

'The osseointegration of an implant is often problematic because soft tissue, not the directly, surrounds the implant. This kind of solution can never be permanent: when the implant is subjected to stress, rapid bone loss ensues, after which the attachment of the implant will fail,' Emilia Kaivosoja, the doctoral candidate, tells.

Cells can be affected by substances, physical forces and hormones

For implant integration, it is important that cells adhere to the surface of the implant as this promotes bone formation or differentiation of progenitor to bone cells. The research found that when the surface of the silicon used in implants was patterned with various materials (diamond-like carbon, chromium, tantalum, or titanium) its with and stem cells was improved.

The research also dealt with three-dimensional surfaces intended to support three-dimensional growth of the cells and activation of the cytoskeleton, which have been found to promote (osteogenesis) in earlier research. Now it was found that activation of the cytoskeleton alone is not sufficient for osteogenesis.

In addition to being affected by substances, cells can be affected by physical forces and hormones. The research showed that pulsed electromagnetic fields improve . It was found that also dehydroepiandrosterone, a sex steroid prohormone, promotes osteogenesis. By combining these two treatments into a two-stage therapy, it may be possible to help patients who suffer from illnesses such as osteoporosis that can negatively affect the adhesion of an implant.

Implant integration and its lifetime are also affected by their contact with normal microbes and pathogens. In the dissertation, it was pointed out that with time-of-flight secondary ion mass spectrometry (ToF-SIMS) bacteria on the surface of implant material can be detected.

Emilia Kaivosoja's dissertation defence takes place in Aalto University School of Electrical Engineering on Friday 15 March 2013 at 12 noon. The title of the thesis is "Improvement of osseointegration".

Explore further: Healing times for dental implants could be cut

Related Stories

Healing times for dental implants could be cut

June 14, 2011
The technology used to replace lost teeth with titanium dental implants could be improved. By studying the surface structure of dental implants not only at micro level but also at nano level, researchers at the University ...

Recommended for you

Study finds walnuts may promote health by changing gut bacteria

July 28, 2017
Research led by Lauri Byerley, PhD, RD, Research Associate Professor of Physiology at LSU Health New Orleans School of Medicine, has found that walnuts in the diet change the makeup of bacteria in the gut, which suggests ...

Green tea ingredient may ameliorate memory impairment, brain insulin resistance, and obesity

July 28, 2017
A study published online in The FASEB Journal, involving mice, suggests that EGCG (epigallocatechin-3-gallate), the most abundant catechin and biologically active component in green tea, could alleviate high-fat and high-fructose ...

Manipulating a type of brain cell gets weight loss results in mice

July 28, 2017
A new study has found something remarkable: the activation of a particular type of immune cell in the brain can, on its own, lead to obesity in mice. This striking result provides the strongest demonstration yet that brain ...

Team finds link between backup immune defense, mutation seen in Crohn's disease

July 27, 2017
Genes that regulate a cellular recycling system called autophagy are commonly mutated in Crohn's disease patients, though the link between biological housekeeping and inflammatory bowel disease remained a mystery. Now, researchers ...

Study finds harmful protein on acid triggers a life-threatening disease

July 27, 2017
Using an array of modern biochemical and structural biology techniques, researchers from Boston University School of Medicine (BUSM) have begun to unravel the mystery of how acidity influences a small protein called serum ...

CRISPR sheds light on rare pediatric bone marrow failure syndrome

July 27, 2017
Using the gene editing technology CRISPR, scientists have shed light on a rare, sometimes fatal syndrome that causes children to gradually lose the ability to manufacture vital blood cells.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.