Acute hypoglycemia impairs executive cognitive function
Alex J. Graveling, M.R.C.P., of the Royal Infirmary of Edinburgh in the United Kingdom, and colleagues studied the effect of acute hypoglycemia on executive function in 32 adults, 16 without diabetes and 16 with type 1 diabetes, who did not have vascular complications or impaired awareness of hypoglycemia. A glucose clamp technique was used to establish hypoglycemic and euglycemic conditions. A validated test suite (Delis-Kaplan Executive Function) was used to assess executive functions.
The researchers found that almost all executive functions were significantly impaired during hypoglycemia compared with euglycemia. Test scores were lower during hypoglycemia, and more time was required for completion of tasks and tests. For some tests, performance during hypoglycemia was worse for those with diabetes than for those without diabetes.
"Executive cognitive function, which is necessary to carry out many everyday activities, is impaired during hypoglycemia in adults with and without type 1 diabetes," the authors write. "The effect size is large in terms of both accuracy and speed."
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