New research findings on onset of uterine fibroids provide potential for novel treatments

Uterine leiomyomata, or fibroids, are benign tumours that nevertheless affect the health of millions of women. They may cause, for instance, pain, bleeding and infertility. Fibroids are also the most common reason for a hysterectomy; for example, some 8,000 hysterectomies are made in Finland each year.

Scientists at the Academy of Finland's Centre of Excellence in Cancer Genetics Research have identified the underlying the onset of common leiomyomata. The results of their research were published in the top medical journal New England Journal of Medicine in early June.

"These new findings are essential for the further development of pharmacological treatments for this type of tumour," says Academy Professor Lauri Aaltonen, who heads the Centre the Excellence based at the University of Helsinki.

Aaltonen's team has demonstrated how the genome of benign uterine leiomyomata differs from normal uterine tissue. Very little was known about the aetiology of leiomyomata before the team's research. The team has previously identified a gene defect that explains more than half of these tumours. The present whole-genome sequencing proved that most of the rest of the tumours develop as a result of chromosome fragmentation and rearrangements.

"Complex chromosomal rearrangements are a major cause of that contribute to the onset of benign uterine leiomyomata," Aaltonen states.

Similar changes resulting from are normally identified in malignant tumours. The results of Aaltonen's team suggest that the same mechanisms may also underlie the onset of non-cancerous tumours.

"Our research also indicates what mechanisms may prevent from becoming malignant," Aaltonen adds.


Explore further

Breakthrough in genetics of fibroids

Journal information: New England Journal of Medicine

Provided by Academy of Finland
Citation: New research findings on onset of uterine fibroids provide potential for novel treatments (2013, June 7) retrieved 1 October 2020 from https://medicalxpress.com/news/2013-06-onset-uterine-fibroids-potential-treatments.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments