Step forward in understanding arterial disease

July 16, 2013

The next step has been made into isolating the origin of cells linked to the progressive disorder Pulmonary Arterial Hypertension.

Further strides have been made into isolating the origin of cells that could lead to a greater understanding of what goes into the development of our blood circulating systems.

University of Lincoln Life Sciences academic Dr Rajiv Machado, with colleagues from the University of Cambridge, King's College London and Papworth Hospital, has revealed the recent findings in a research letter to The American Journal of Respiratory and Critical Care Medicine.

Dr Machado's main research area is in Pulmonary Arterial Hypertension (PAH) which is a progressive disorder characterised by abnormally (hypertension) in the , the blood vessel that carries blood from the heart to the lungs.

Symptoms are shortness of breath, dizziness, swelling (oedema) of the ankles or legs, chest pain and a racing pulse.

In this latest study, researchers investigated genetically identical twins, both of which had the responsible for PAH.

However, only one had the disorder which resulted in both a heart and lung transplant.From this starting block, the team were able to investigate the origin of blood outgrowth endothelial cells (BOEC), which are and good candidates for vascular (re-) generating cell therapy. However, uncertainty remains as to the specific origin of these cells. 

The researchers study of the twins and the mutation they both harboured enabled them to identify a marker to show that those stem cells, the BOECs, were very unlikely to have come from the heart or lungs.

Dr Machado said: "When the circulating BOECs were cultured from the new heart and lungs they still showed the mutation. Hence, they must have been produced in a different organ/s. The importance of this is that scientists are keen to know the origin of these cells both as a proxy for basic science and to provide an understanding of what goes into the development of our blood circulating systems. If we can in one fell swoop remove two organs as being contributory then we are another step closer to knowing where these cells come from."

Explore further: Research findings breathe new life into lung disease

More information: Mark L. Ormiston, Laura Southgate, Carmen Treacy, Joanna Pepke-Zaba, Richard C. Trembath, Rajiv D. Machado, and Nicholas W. Morrell "Assessment of a Pulmonary Origin for Blood Outgrowth Endothelial Cells by Examination of Identical Twins Harboring a BMPR2 Mutation", American Journal of Respiratory and Critical Care Medicine, Vol. 188, No. 2 (2013), pp. 258-260.

Related Stories

Research findings breathe new life into lung disease

October 24, 2012
It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood ...

Disruption of cellular signaling identified in pulmonary arterial hypertension

December 27, 2012
(Medical Xpress)—Impairment of a key signaling cascade in the pulmonary blood vessels plays an important role in pulmonary arterial hypertension, a Yale study has found. The study appears in the advance online publication ...

Breakthrough could help sufferers of fatal lung disease

October 15, 2012
Pioneering research conducted by the University of Sheffield is paving the way for new treatments which could benefit patients suffering from the fatal lung disease pulmonary arterial hypertension (PAH).

Why is pulmonary hypertension at high altitude so common and dangerous?

June 27, 2013
Everyone who climbs to high altitude will develop pulmonary hypertension, a temporary constriction of blood vessels that results in increasing strain on the right heart. It is a normal adaptive mechanism but if exaggerated ...

Sleep apnea and pre-eclampsia share a common warning sign

June 27, 2013
Many, but not all, people with sleep apnea develop high blood pressure. In a new study, Yale researchers show those who develop hypertension have many similarities with pregnant woman with pre-eclampsia.

New study may lead to quicker diagnosis, improved treatment for fatal lung disease

July 11, 2011
One-fifth of all patients with pulmonary arterial hypertension suffer with the fatal disease for more than two years before being correctly diagnosed and properly treated, according to a new national study led by researchers ...

Recommended for you

Could aggressive blood pressure treatments lead to kidney damage?

July 18, 2017
Aggressive combination treatments for high blood pressure that are intended to protect the kidneys may actually be damaging the organs, new research from the University of Virginia School of Medicine suggests.

Quantifying effectiveness of treatment for irregular heartbeat

July 17, 2017
In a small proof-of-concept study, researchers at Johns Hopkins report a complex mathematical method to measure electrical communications within the heart can successfully predict the effectiveness of catheter ablation, the ...

Concerns over side effects of statins stopping stroke survivors taking medication

July 17, 2017
Negative media coverage of the side effects associated with taking statins, and patients' own experiences of taking the drugs, are among the reasons cited by stroke survivors and their carers for stopping taking potentially ...

Study discovers anticoagulant drugs are being prescribed against safety advice

July 17, 2017
A study by researchers at the University of Birmingham has shown that GPs are prescribing anticoagulants to patients with an irregular heartbeat against official safety advice.

Protein may protect against heart attack

July 14, 2017
DDK3 could be used as a new therapy to stop the build-up of fatty material inside the arteries

Heart study finds faulty link between biomarkers and clinical outcomes

July 14, 2017
Surrogate endpoints (biomarkers), which are routinely used in clinical research to test new drugs, should not be trusted as the ultimate measure to approve new health interventions in cardiovascular medicine, according to ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.