Breast CA nodal mets more common with certain mutations

July 25, 2013
Breast CA nodal mets more common with certain mutations
Lymph node metastases are more common in breast cancers with mutations in a cellular signaling pathway associated with growth, according to a study published online July 24 in JAMA Surgery.

(HealthDay)—Lymph node metastases are more common in breast cancers with mutations in a cellular signaling pathway associated with growth, according to a study published online July 24 in JAMA Surgery.

Cory A. Donovan, M.D., from the Oregon Health & Science University in Portland, and colleagues analyzed 30 invasive ductal breast cancers (stages IA through IIIB) for mutations in the AKT1, HRAS, and PIK3CA genes in stem and progenitor cells and their association with various demographic and clinical factors.

The researchers found that 10 tumors had mutations. The presence of lymph node was significantly more common when were present (90 versus 20 percent).

"Tumors in which breast cancer stem and progenitor cells have defects in PI3K/Akt signaling are significantly more likely to manifest nodal metastases," Donovan and colleagues conclude. "These oncogenic defects may be missed by gross molecular testing of the tumor and are markers of more aggressive breast cancer."

Explore further: Researchers discover molecule that drives aggressive breast cancer

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Researchers discover molecule that drives aggressive breast cancer

July 1, 2013
(Medical Xpress)—Recent studies by researchers at Thomas Jefferson University's Kimmel Cancer Center have shown a gene known to coordinate initial development of the eye (EYA1) is a powerful breast tumor promoter in mice. ...

Malignant stem cells may explain why some breast cancers develop and recur

August 16, 2011
Mutations that are found in stem cells could be causing some breast cancers to develop and may be the reason the disease recurs. These abnormal cells are likely controlling cell functions in the tumor and, given they are ...

New breast cancer model of mutant PI3K recapitulates features of human breast cancer

July 12, 2011
Scientists from the Friedrich Miescher Institute for Biomedical Research have shown that a mutation in the lipid kinase PI3K, which occurs in about 30% of human breast cancers, itself evokes different forms of breast cancer. ...

Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy

December 5, 2012
Most patients whose breast cancer has spread to their lymph nodes have most of the lymph nodes in their armpit area removed after chemotherapy to see if any cancer remains. A study conducted through the American College of ...

Pretreatment PET/CT imaging of lymph nodes predicts recurrence in breast cancer patients

September 4, 2012
Disease-free survival for invasive ductal breast cancer (IDC) patients may be easier to predict with the help of F-18-fludeoxyglucose positron emission tomography (PET)/computed tomography (CT) scans, according to research ...

Inhibiting cell migration in breast cancer

March 14, 2012
(Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research together with colleagues from the University of Fribourg have discovered a signaling mechanism controlling mobility and metastasis ...

Recommended for you

Cancer-death button gets jammed by gut bacterium

July 27, 2017
Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy ...

Researchers release first draft of a genome-wide cancer 'dependency map'

July 27, 2017
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes ...

Long-sought mechanism of metastasis is discovered in pancreatic cancer

July 27, 2017
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power ...

Blocking the back-door that cancer cells use to escape death by radiotherapy

July 27, 2017
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study.

Manmade peptides reduce breast cancer's spread

July 27, 2017
Manmade peptides that directly disrupt the inner workings of a gene known to support cancer's spread significantly reduce metastasis in a mouse model of breast cancer, scientists say.

Glowing tumor technology helps surgeons remove hidden cancer cells

July 27, 2017
Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) - through the use of a contrast agent that makes tumor cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.