World's first IVF baby born after preimplantation genome sequencing is now 11 months old

July 22, 2013, BGI Shenzhen

The largest genomic institute of the world, BGI Shenzhen, China (hereinafter BGI), together with Reproductive & Genetic Hospital CITIC-XIANGYA (hereinafter CITIC-XIANGYA) announced today that they have successfully applied Next Generation Sequencing (NGS) to detect in vitro fertilized (IVF) embryos with genetic abnormalities. The successful application of preimplantation sequencing (the most advanced form of preimplantation genetic screening, PGS) opens a new chapter in the field of human assisted reproduction, providing new hopes for IVF couples.

In preimplantation sequencing, 7 to 12 cells are removed from morphologically normal human embryos 5 days after fertilization in vitro. Embryos are subsequently cryopreserved by vitrification, and samples are analyzed by using the latest DNA technologies to detect abnormalities. Only genetically intact embryos are transferred to the uterus during the subsequent cycle, with minimal or no hormonal stimulation.

Since 2010, as a result of collaboration between BGI and CITIC-XIANGYA, sequenced embryos from 33 couples were transferred, and 22 pregnancies were achieved. The success rate was 66.7%. Up to now, 17 healthy babies were born.

On August 24, 2012, the world's first IVF baby sequenced before implantation was born in Hunan Province, China. Five days after fertilization in vitro, 7 embryos were biopsied and all samples were shipped to BGI for preimplantation sequencing. Based on a combination of NGS and bioinformatics analysis, 3 embryos were found to have normal chromosomal content and two of them were selected for transfer resulting in pregnancy. The baby is now 11 months old, healthy and developing normally.

On the 29th Annual Meeting of the European Society for Human Reproduction and Embryology (ESHRE) London, 7-11 July, 2013, research findings of BGI and CITIC- XIANGYA were presented in the lecture of Dr. Jian Li and colleagues from BGI, creating considerable acknowledgement among experts worldwide. In the next talk, Dr. Dagan Wells and colleagues from Oxford University announced the birth of the first IVF baby of the Western Hemisphere after genomic sequencing in England.

Professor Guangxiu Lu, President of CITIC XIANGYA and one of the founders and pioneers in human in China called the birth as a landmark event in human IVF. As sequencing is the most accurate method for detection of genetic anomalies, doctors can transfer the best of the cohort, this way pregnancy rates may be increased and the chance of abnormalities of genetic origin decreased.

Dr. Yutao Du, Vice-President of BGI Health Group said that with the introduction of new procedures, the cost of sequencing has decreased dramatically. Accordingly, preimplantation sequencing will become a choice for more and more IVF couples. The accuracy is increasing continuously, and new bioinformatic analysis approaches enable scientists to detect specific genetic disorders, even from single cells. Accordingly, preimplantation sequencing may have a crucial role in improving the efficiency and safety of human assisted reproduction.

Explore further: First child born following embryo screening with new genome analysis technique

Related Stories

First child born following embryo screening with new genome analysis technique

July 7, 2013
The first birth has been achieved following the analysis of embryos using a new genome sequencing technique which promises to revolutionise embryo selection for IVF. The technique, which has never before been applied in the ...

Breakthrough for IVF?

May 16, 2013
Elsevier today announced the publication of a recent study in Reproductive BioMedicine Online on 5-day old human blastocysts showing that those with an abnormal chromosomal composition can be identified by the rate at which ...

Sampling of embryonic DNA after IVF without biopsy

April 2, 2013
New study published in Reproductive Biomedicine Online shows that fluid-filled cavity in 5-day old human blastocysts may contain DNA from the embryo, allowing diagnosis of genetic disease without a biopsy

Improvements in embryonic preimplantation genetic screening techniques

April 13, 2011
A Short Comparative Genomic Hybridisation (CGH) method has been developed to carry out preimplantation genetic screening (PGS) by analysing all chromosomes and transferring selected embryos to the recipient uterus in the ...

New genetic testing technology for IVF embryos

May 23, 2011
Researchers at the Johns Hopkins University School of Medicine have devised a new technique, which helps couples that are affected by or are carriers of genetic diseases have in vitro fertilized babies free of both the disease ...

Low-cost in-vitro fertilization method may help couples in developing countries (Update)

July 8, 2013
A new low-cost method of in-vitro fertilization developed at the University of Colorado Boulder that performed successfully in recent human clinical trials in Belgium may help thousands of infertile couples in developing ...

Recommended for you

Secrets of longevity protein revealed in new study

January 17, 2018
Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure ...

Weight flux alters molecular profile, study finds

January 17, 2018
The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine.

The HLF gene protects blood stem cells by maintaining them in a resting state

January 17, 2018
The HLF gene is necessary for maintaining blood stem cells in a resting state, which is crucial for ensuring normal blood production. This has been shown by a new research study from Lund University in Sweden published in ...

Magnetically applied MicroRNAs could one day help relieve constipation

January 17, 2018
Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. As a growing concern, researchers look to new tools to help patients with this side effect of opioid use and aging.

Researchers devise decoy molecule to block pain where it starts

January 16, 2018
For anyone who has accidentally injured themselves, Dr. Zachary Campbell not only sympathizes, he's developing new ways to blunt pain.

Scientists unleash power of genetic data to identify disease risk

January 16, 2018
Massive banks of genetic information are being harnessed to shed new light on modifiable health risks that underlie common diseases.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.