Scientists 'grow' new cartilage with help of 3-D printing technology

August 8, 2013
Professor Gordon Wallace (right) and Dr Johnson Chung inspect 3D printed biomaterials used to create implantable scaffolds for nerve and tissue regeneration as part of ACES' bionics research program. Credit: Mark Newsham

A partnership between scientists at the University of Wollongong and St Vincent's Hospital Melbourne has led to a breakthrough in tissue engineering, with researchers growing cartilage from stem cells to treat cancers, osteoarthritis and traumatic injury.

In work led by Associate Professor Damian Myers of St Vincent's Hospital Melbourne – a node of the UOW-headquartered Australian Research Council Centre of Excellence for Electromaterials Science (ACES) – scaffolds fabricated on 3D printing equipment were used to grow over a 28-day period from stem cells that were extracted from tissue under the knee cap.

Professor Myers said this was the first time true cartilage had been grown, as compared to "fibrocartilage", which does not work long-term.

"We are trying to create a tissue environment that can 'self-repair' over many years, meaning the repaired site will not deteriorate," he said.

"It's very exciting work, and we've done the hard yards to show that what we have cultured is what we want for use in surgery for ."

ACES Director Professor Gordon Wallace and his team developed customised fabrication equipment to deliver live cells inside a printed 3D structure. This was utilised to deliver 3D printed scaffolds on which the cartilage was grown.

"ACES has established a biomedical 3D printing lab at St Vincent's Hospital Melbourne in April this year. This has greatly accelerated progress by bringing clinicians and face to face on a daily basis," Professor Wallace said.

This research, which will soon move to pre-clinical trials to demonstrate repair of cartilage, is part of a wider project, involving Professor Wallace, Professor Mark Cook and Professor Peter Choong through the Aikenhead Centre for Medical Discovery. The aim is to eventually use a patient's own stem cells to grow muscles, fat, bone and tendons.

Professor Wallace and his team are also working to develop custom-made 3D printed human organs.

"By 2025, it is feasible that we will be able to fabricate complete functional organs, tailored for an individual patient," he said.

Professor Wallace will give a free public lecture on UOW's research into 3D printing with on Thursday 15 August at the 2013 Bill Wheeler Symposium.

Explore further: Can we use 3-D printing and stem cells to build a bone?

Related Stories

Better cartilage repairs using stem cells

March 21, 2013

Using adult stem cells is a good way of culturing better-quality cartilage to repair worn hips and knees. New cartilage that has good properties can be grown in particular by cultivating adult stem cells in combination with ...

Recommended for you

Success in the 3-D bioprinting of cartilage

April 28, 2017

A team of researchers at Sahlgrenska Academy has managed to generate cartilage tissue by printing stem cells using a 3-D-bioprinter. The fact that the stem cells survived being printed in this manner is a success in itself. ...

Mouse teeth providing new insights into tissue regeneration

April 27, 2017

Researchers hope to one day use stem cells to heal burns, patch damaged heart tissue, even grow kidneys and other transplantable organs from scratch. This dream edges closer to reality every year, but one of the enduring ...

Dentistry research ID's novel marker for left-handedness

April 27, 2017

Individuals with a slender lower face are about 25 percent more likely to be left-handed. This unexpected finding was identified in 13,536 individuals who participated in three national surveys conducted in the United States.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.