Tracking nanodiamond-tagged stem cells

August 5, 2013

A method that is used to track the fate of a single stem cell within mouse lung tissue is reported in a study published online this week in Nature Nanotechnology. The method may offer insights into the factors that determine the acceptance of transplanted stem cells, and their ability to regenerate within a host.

Stem cell therapy has the potential to repair and regenerate damaged tissues. Implanted cells might, however, be rejected, migrate or die; tracking in vivo may help to further understand what happens once these cells are inside the host.

Huan-Cheng Chang and colleagues used fluorescent nanodiamonds to tag lung stem cells and implant them in mice with damaged lungs. They found that not only did the damaged of the mice restore rapidly, but that the uptake and regeneration of stem cells could be tracked with single-cell resolution. The authors suggest that, in the future, the technique could also be used to monitor the uptake of different kinds of stem cell, such as bone marrow stem cells.

Explore further: Boning up: Researchers find home of best stem cells for bone marrow transplants

More information: DOI: 10.1038/nnano.2013.147

Related Stories

Boning up: Researchers find home of best stem cells for bone marrow transplants

August 1, 2013
McMaster University researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone.

US researchers identify first human lung stem cell

May 11, 2011
For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including ...

New study refutes existence and clinical potential of very small embryonic-like stem cells

July 24, 2013
Scientists have reported that very small embryonic-like stem cells (VSELs), which can be isolated from blood or bone marrow rather than embryos, could represent an alternative to mouse and human embryonic stem cells for research ...

Stem cells aid recovery from stroke

January 27, 2013
Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central's open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain ...

Stem cells in urine easy to isolate and have potential for numerous therapies

July 31, 2013
Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem ...

Recommended for you

Post-stroke patients reach terra firma with new exosuit technology

July 26, 2017
Upright walking on two legs is a defining trait in humans, enabling them to move very efficiently throughout their environment. This can all change in the blink of an eye when a stroke occurs. In about 80% of patients post-stroke, ...

Brain cells found to control aging

July 26, 2017
Scientists at Albert Einstein College of Medicine have found that stem cells in the brain's hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related ...

Molecular hitchhiker on human protein signals tumors to self-destruct

July 24, 2017
Powerful molecules can hitch rides on a plentiful human protein and signal tumors to self-destruct, a team of Vanderbilt University engineers found.

Researchers develop new method to generate human antibodies

July 24, 2017
An international team of scientists has developed a method to rapidly produce specific human antibodies in the laboratory. The technique, which will be described in a paper to be published July 24 in The Journal of Experimental ...

New vaccine production could improve flu shot accuracy

July 24, 2017
A new way of producing the seasonal flu vaccine could speed up the process and provide better protection against infection.

A sodium surprise: Engineers find unexpected result during cardiac research

July 20, 2017
Irregular heartbeat—or arrhythmia—can have sudden and often fatal consequences. A biomedical engineering team at Washington University in St. Louis examining molecular behavior in cardiac tissue recently made a surprising ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.