Pre-op pregabalin best for pain in spinal surgery

Pre-op pregabalin best for pain in spinal surgery

(HealthDay)—Preoperative pregabalin is superior to either gabapentin or placebo for the relief of pain in patients undergoing lumbar discectomy, according to a study published in the March 15 issue of Spine.

Gurjeet Khurana, M.D., from HIHT University in Dehradun, India, and colleagues compared 300 mg of (Group A), 75 mg of pregabalin (Group B), or placebo (Group C) in 90 patients (aged 18 to 75 years) undergoing spinal surgery. One dose was given one hour before surgery and at eight hour intervals for seven days afterwards. Postoperative static and dynamic pain and functional outcome were assessed using a visual analogue scale, the Prolo functional and economic score, and the Oswestry Disability Index score, both preoperatively and three months postoperatively.

The researchers found that subjects receiving pregabalin showed consistently reduced static and dynamic pain intensity and also required a lesser amount of rescue drug throughout the . At all time intervals there was a statistically significant difference (P < 0.05) in the Prolo score and the Oswestry Disability Index score between group B and group C. There was a significant difference in the functional outcome between group A and group B at three months.

"Preoperative pregabalin administration is associated with less pain intensity and improved functional outcomes three months after lumbar discectomy followed by gabapentin and then ," the authors write.


Explore further

Gabapentin doesn't cut use of morphine post-knee arthroplasty

More information: Full Text
Journal information: Spine

Copyright © 2014 HealthDay. All rights reserved.

Citation: Pre-op pregabalin best for pain in spinal surgery (2014, March 28) retrieved 19 November 2019 from https://medicalxpress.com/news/2014-03-pre-op-pregabalin-pain-spinal-surgery.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments