Salivary biomarkers of gingivitis: Information important for personalized decision-making

March 21, 2014

Today during the 43rd Annual Meeting & Exhibition of the American Association for Dental Research, held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, Craig Miller, University of Kentucky, Lexington, will present research titled "Salivary Biomarkers of Gingivitis: Information Important for Personalized Decision-Making."

Salivary biomarkers have been studied to help determine the presence, risk, and progression of periodontal disease. However, clinical translation of salivary biomarkers from bench to chairside requires studies that identify biomarkers associated with the continuum of phases between health and periodontal disease. Thus, the objective of this study was to identify salivary biomarkers associated with .

Forty gingivitis subjects and 40 persons with gingival health who had more than 20 teeth were studied. Unstimulated saliva was collected from all subjects at baseline and seven to 30 days later, an additional sample was collected from gingivitis subjects seven to 30 days post-dental prophylaxis. Clinical parameters of were recorded at baseline and the final visit. Salivary concentrations were measured using Luminex.

Gingivitis subjects had significantly higher bleeding on probing (BOP), plaque index and gingival index than healthy subjects (P<0.002). All gingivitis subjects showed a significant drop in BOP post-treatment, with 90% of subjects falling below 12% affected sites. Concentrations of MIP-1a and PGE2 were significantly higher in the gingivitis group than the healthy group (2.4X and 2.1X, respectively; P<0.003). IL-1 was the only biomarker that showed a significant decrease in mean concentration after dental prophylaxis in the gingivitis group. Individuals with elevated levels of PGE2 +/- the other biomarkers were > 35.3X more likely to have gingivitis as determined by odd ratio analyses (P=0.001).

These findings indicate that salivary PGE2 has the potential for discriminating gingivitis from health. Also, patients who return to health clinically after dental prophylaxis appear to continue to produce inflammatory mediators for weeks. These findings have potential important implications on the decision-making process in the emerging field of personalized oral health care. This research is supported by NIGMS P20GM103538, UL1TR000117 and the IADR Innovation in Oral Health Award.

Explore further: Resin infiltration effects in a caries-active environment—two year results

More information: This is a summary of abstract #834, "Salivary Biomarkers of Gingivitis: Information Important for Personalized Decision-Making," which will be presented on Friday, March 21, 2014, 10:45 a.m. – 12:15 p.m. at the Charlotte Convention Center, room 203A.

Related Stories

Resin infiltration effects in a caries-active environment—two year results

March 20, 2014
Today during the 43rd Annual Meeting & Exhibition of the American Association for Dental Research, held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, Mathilde C. Peters, University ...

Injectable progesterone contraceptives may be associated with poor periodontal health

February 6, 2012
Injectable progesterone contraceptives may be associated with poor periodontal health, according to research in the Journal of Periodontology. The study found that women who are currently taking depotmedroxyprogesterone acetate ...

Study links tooth loss to depression and anxiety

March 20, 2014
Today, at the 43rd Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, R. Constance Wiener, ...

Periodontal therapy reduces hospitalizations and medical care costs in diabetics

March 23, 2012
Today, during the 41st Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 36th Annual Meeting of the Canadian Association for Dental Research, an abstract titled ...

Antibacterial agent boosts toothpaste effectiveness

January 10, 2014
Regular use of fluoride toothpaste containing triclosan, an antibacterial agent, and a copolymer, which helps prevent the triclosan from being washed away by saliva, reduces plaque, gingivitis, and bleeding gums and slightly ...

Adeno-associated virus serotype-5 delivery to the rat trigeminal ganglion

March 21, 2014
Today during the 43rd Annual Meeting & Exhibition of the American Association for Dental Research, held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, Lauren Roper, University ...

Recommended for you

Understanding genetic synergy in cleft palate

July 19, 2017
Like all of the individual elements of fetal development, palate growth is a marvel of nature. In part of this process, ledges of tissue on the sides of the face grow downwards on each side of the tongue, then upward, fusing ...

Use of prefabricated blood vessels may revolutionize root canals

June 12, 2017
While root canals are effective in saving a tooth that has become infected or decayed, this age-old procedure may cause teeth to become brittle and susceptible to fracture over time. Now researchers at OHSU in Portland, Oregon, ...

Recreational cannabis, used often, increases risk of gum disease

May 24, 2017
Columbia University dental researchers have found that frequent recreational use of cannabis—including marijuana, hashish, and hash oil—increases the risk of gum disease.

Grape seed extract could extend life of resin fillings

May 9, 2017
A natural compound found in grape seed extract could be used to strengthen dentin—the tissue beneath a tooth's enamel—and increase the life of resin fillings, according to new research at the University of Illinois at ...

Crooked bite may indicate early life stress

April 13, 2017
Research has repeatedly confirmed that the first 1,000 days after conception strongly influence a person's life expectancy and susceptibility to chronic diseases. The primary marker used to identify early life stress is low ...

New study identifies successful method to reduce dental implant failure

March 24, 2017
According to the American Academy of Implant Dentistry (AAID), 15 million Americans have crown or bridge replacements and three million have dental implants—with this latter number rising by 500,000 a year. The AAID estimates ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.