Exercise ups mitochondrial biogenesis in adipose tissue

Exercise ups mitochondrial biogenesis in adipose tissue

(HealthDay)—Exercise training increases mitochondrial biogenesis, mitochondrial DNA (mtDNA) content, and glucose uptake in the subcutaneous adipose tissue of wild type, but not endothelial nitric oxide synthase (eNOS) knockout mice, according to research published online March 12 in Diabetes.

Elisabetta Trevellin, Ph.D., of the University of Padua in Italy, and colleagues conducted studies in mice and cell cultures of murine and human adipocytes to investigate the effects of exercise on mitochondria and glucose metabolism in adipose tissue.

The researchers found that swim training resulted in in vivo effects of increases in mitochondrial biogenesis, mtDNA uptake, and glucose uptake in of wild type, but not eNOS knockout, mice. In vitro studies showed that treatment with a donor stimulated mitochondrial biogenesis and elongation as well as and GLUT4 translocation in cultured murine and human adipocytes.

"These results point to the crucial role of the eNOS-derived nitric oxide in the metabolic adaptation of subcutaneous adipose tissue to exercise training," the authors write.


Explore further

Telmisartan reverses insulin resistance in mice

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Diabetes

Copyright © 2014 HealthDay. All rights reserved.

Citation: Exercise ups mitochondrial biogenesis in adipose tissue (2014, March 20) retrieved 7 December 2019 from https://medicalxpress.com/news/2014-03-ups-mitochondrial-biogenesis-adipose-tissue.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments