Disruption of VISTA plays an important role in regulating immune response

April 7, 2014, The Geisel School of Medicine at Dartmouth

Researchers at the Geisel School of Medicine at Dartmouth have found that the body's immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors. The study, "VISTA deficiency synergizes with a nonredundant immune checkpoint pathway and leads to enhanced immune activation," will be presented on April 7, 2014 at the American Association for Cancer Research Annual Meeting in San Diego, CA.

"Because there are multiple immune suppressive pathways, disrupting a single pathway like VISTA might not have led us to obvious alterations in the ," said Li Wang, PhD, assistant professor of Microbiology and Immunology at Geisel. "Our data showed clear chronic inflammation due to VISTA deficiency, which leads us to conclude that VISTA likely plays an important role in regulating immunity."

Wang and her colleagues hope to build on these findings to define the molecular pathway involved in VISTA-mediated immune regulation.

Explore further: New drug has potential to treat broader range of cancers

Related Stories

New drug has potential to treat broader range of cancers

September 10, 2012
(Medical Xpress)—ImmuNext, founded by scientists at King's College London, has announced a  research and drug development agreement with Janssen Biotech Inc to develop a new cancer drug to trigger the body's own immune ...

​Screening reveals additional link between endometriosis and ovarian cancer

April 4, 2014
(Medical Xpress)—Some women with endometriosis, a chronic inflammatory disease, are predisposed to ovarian cancer, and a genetic screening might someday help reveal which women are most at risk, according to a University ...

Immunology researchers uncover pathways that direct immune system to turn 'on' or 'off'

March 18, 2014
(Medical Xpress)—A key discovery explaining how components of the immune system determine whether to activate or to suppress the immune system, made by Kelvin Lee, MD, Professor of Oncology and Co-Leader of the Tumor Immunology ...

Bacteria may assist the immune system response against cancer

March 3, 2014
(Medical Xpress)—Recent research from the University of Otago shows that bacteria may assist the body's immune system response against cancer cells and help fight tumours like melanoma.

Discovery brings cancer immune therapies a step closer

February 5, 2014
(Medical Xpress)—The development of new therapies to enhance the body's immune response to cancer is much closer after University of Otago scientists identified a pathway that alters the immune response in the spleen and ...

Researchers find promising results with local hyperthermia of tumors

March 4, 2014
A combination of iron-oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumors in mice according to an accepted manuscript by Dartmouth-Hitchcock ...

Recommended for you

Immunosuppressive cells in newborns play important role in controlling inflammation in early life

January 15, 2018
New research led by The Wistar Institute, in collaboration with Sun Yat-sen University in China, has characterized the transitory presence of myeloid-derived suppressor cells (MDSCs) in mouse and human newborns, revealing ...

Memory loss from West Nile virus may be preventable

January 15, 2018
More than 10,000 people in the United States are living with memory loss and other persistent neurological problems that occur after West Nile virus infects the brain.

Mould discovery in lungs paves way for helping hard to treat asthma

January 15, 2018
A team at The University of Manchester have found that in a minority of patients they studied, a standard treatment for asthma—oral steroids—was associated with increased levels of the treatable mould Aspergillus in the ...

Fast food makes the immune system more aggressive in the long term

January 12, 2018
The immune system reacts similarly to a high fat and high calorie diet as to a bacterial infection. This is shown by a recent study led by the University of Bonn. Particularly disturbing: Unhealthy food seems to make the ...

Past exposures shape immune response in pediatric acute respiratory infections

January 12, 2018
Acute respiratory tract infections (ARTI) are the leading global cause of death in early childhood, according to the Centers for Disease Control and Prevention (CDC). Lower respiratory tract infections, including bronchiolitis ...

Scientists identify immune cells that keep gut fungi under control

January 11, 2018
Immune cells that process food and bacterial antigens in the intestines control the intestinal population of fungi, according to a new study from Weill Cornell Medicine scientists. Defects in the fungus-fighting abilities ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.