Six-minute walk test could help guide heart failure treatment

April 15, 2014
Six-minute walk test could help guide heart failure treatment

(HealthDay)—Distance achieved in the six-minute walk test may be a practical measure of functional capacity that guides selection of therapy for patients with heart failure, according to research published online April 9 in the Journal of the American College of Cardiology.

Daniel P. Fishbein, M.D., of Duke University in Durham, N.C., and colleagues conducted a six-minute walk test in 2,397 patients with prior to random assignment in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). The researchers assessed the association between the distance on the six-minute walk test and mortality according to treatment selection.

The researchers found that risk of mortality for with an implantable cardioverter defibrillator (ICD) versus placebo according to hazard ratio [HR] for tertiles of distance on the six-minute walk test was 0.42 (95 percent confidence interval [CI], 0.26 to 0.66) for the top tertile, greater than 386 m; 0.57 (95 percent CI, 0.39 to 0.83) for the middle tertile, 288 to 386 m; and 1.02 (95 percent CI, 0.75 to 1.39) for the bottom tertile, less than 288 m. The corresponding HRs for amiodarone therapy versus placebo were 0.68 (95 percent CI, 0.46 to 1.02) for the top tertile, 0.86 (95 percent CI, 0.61 to 1.21) for the middle tertile, and 1.56 (95 percent CI, 1.17 to 2.09) for the bottom tertile of distance on the six-minute walk test. In a secondary analysis of cause-specific mortality, ICD therapy reduced arrhythmic mortality in the top two tertiles of the six-minute walk test but had no effect on heart failure mortality.

"In summary, patients with a six-minute walk distance of less than 288 meters did not derive benefit from either prophylactic implantation or amiodarone therapy," the authors write.

Several pharmaceutical companies contributed funding to the SCD-HeFT trial.

Explore further: Interarm BP difference may up cardiac risk in diabetes

More information: Full Text (subscription or payment may be required)

Related Stories

Interarm BP difference may up cardiac risk in diabetes

April 3, 2014
(HealthDay)—Interarm differences in systolic blood pressure (BP) in patients with diabetes may be associated with an increased risk of cardiovascular morbidity and mortality, according to research published online on March ...

Nocturnal respiratory rate predicts cardiac risk after MI

March 10, 2014
(HealthDay)—Among survivors of acute myocardial infarction (MI), nocturnal respiratory rate (NRR) is significantly associated with cardiac mortality, particularly non-sudden cardiac death, according to research published ...

Clopidogrel after MI less effective in diabetes patients

September 5, 2012
(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue of the Journal ...

Improved outcomes seen with ventricular assist devices

January 31, 2014
(HealthDay)—Among Medicare patients receiving implantation of ventricular assist devices (VADs) for advanced heart failure, mortality has decreased, but readmission rates did not change, according to research published ...

Melanoma risk up in IBD independent of biologic therapy

January 31, 2014
(HealthDay)—Inflammatory bowel disease (IBD) is associated with an increased risk of melanoma, independent of the use of biologic therapy, according to research published in the February issue of Clinical Gastroenterology ...

Coffee consumption linked with reduced risk of diabetes

February 17, 2014
(HealthDay)—Higher consumption of coffee is associated with lower risk of type 2 diabetes, according to research published in the February issue of Diabetes Care.

Recommended for you

Could aggressive blood pressure treatments lead to kidney damage?

July 18, 2017
Aggressive combination treatments for high blood pressure that are intended to protect the kidneys may actually be damaging the organs, new research from the University of Virginia School of Medicine suggests.

Quantifying effectiveness of treatment for irregular heartbeat

July 17, 2017
In a small proof-of-concept study, researchers at Johns Hopkins report a complex mathematical method to measure electrical communications within the heart can successfully predict the effectiveness of catheter ablation, the ...

Concerns over side effects of statins stopping stroke survivors taking medication

July 17, 2017
Negative media coverage of the side effects associated with taking statins, and patients' own experiences of taking the drugs, are among the reasons cited by stroke survivors and their carers for stopping taking potentially ...

Study discovers anticoagulant drugs are being prescribed against safety advice

July 17, 2017
A study by researchers at the University of Birmingham has shown that GPs are prescribing anticoagulants to patients with an irregular heartbeat against official safety advice.

Protein may protect against heart attack

July 14, 2017
DDK3 could be used as a new therapy to stop the build-up of fatty material inside the arteries

Heart study finds faulty link between biomarkers and clinical outcomes

July 14, 2017
Surrogate endpoints (biomarkers), which are routinely used in clinical research to test new drugs, should not be trusted as the ultimate measure to approve new health interventions in cardiovascular medicine, according to ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.