Decrease in fat cell volume improves insulin sensitivity

May 13, 2014
Decrease in fat cell volume improves insulin sensitivity

(HealthDay)—For obese women, a reduction in fat cell volume after bariatric surgery is strongly associated with improvement in insulin sensitivity, with the peak incidence seen among older women, according to a study published online April 23 in Diabetes Care.

Daniel P. Andersson, from the Karolinska Institutet in Stockholm, and colleagues examined whether changes in volume and correlate with improvements in metabolic risk profile in a cohort of 62 who underwent Roux-en-Y gastric bypass (RYGB). Fat cell volume and number were measured in abdominal subcutaneous adipose tissue before and after RYGB.

The researchers observed a 33 percent decrease in body weight with RYGB, which was accompanied by a decrease in the volume, but not number, of adipocytes. After RYGB, there was a decrease in fat mass in the measured regions and improvement in all metabolic parameters (P < 0.0001). A strong correlation was seen for reduced subcutaneous fat and improved insulin sensitivity (P = 0.0057), but this correlation was not seen for regional changes in fat mass, except for weak associations between changes in visceral fat mass, insulin sensitivity, and triglycerides. After weight loss, there was an alteration in the curve-linear relationship between fat cell size and fat mass (P = 0.03).

"An altered relationship between adipocyte size and fat mass may be important for improving insulin sensitivity after weight loss," the authors write. "Fat cell size reduction could constitute a target to improve ."

The study was partially funded by the Novo Nordisk Foundation and the European Association for the Study of Diabetes/Lilly.

Explore further: Snacking contributes to fatty liver and abdominal obesity

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Snacking contributes to fatty liver and abdominal obesity

May 6, 2014
Researchers from The Netherlands found that snacking on high-fat and high-sugar foods was independently associated with abdominal fat and fatty liver (hepatic steatosis). According to the study published in Hepatology, a ...

Diet rich in unsaturated fat may up insulin sensitivity

June 14, 2013
(HealthDay)—A diet rich in unsaturated fat may increase insulin sensitivity in individuals who are at higher risk for cardiovascular disease, according to research published in the May issue of Diabetes Care.

A protein could be a key weapon in the battle of the bulge

April 1, 2014
More than one-third of people in the US are obese. Obesity and its related health problems—including high blood pressure, high cholesterol, diabetes, insulin resistance, and belly fat—affect so many, yet effective treatments ...

Genetic variant may explain weight loss post-RYGB surgery

May 7, 2013
(HealthDay)—A genetic variant associated with weight loss after Roux-en-Y gastric bypass (RYGB) surgery has been identified, according to a study published in the May 2 issue of the American Journal of Human Genetics.

Radiographic imaging exposes relationship between obesity and cancer

December 4, 2013
Researchers at the National Institute for Aging are working to improve understanding about obesity and cancer. A study, published today in the journal Applied Physiology, Nutrition, and Metabolism, is the first to use direct ...

Recommended for you

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.