Calcium and vitamin D supplementation improves metabolic profile of pregnant women with gestational diabetes

June 23, 2014, Diabetologia

New research published in Diabetologia, the journal of the European Association for the Study of Diabetes, shows that calcium and vitamin D supplementation improves the metabolic profile of pregnant women with gestational diabetes. The research is by Dr Ahmad Esmaillzadeh, Isfahan University of Medical Sciences, Isfahan, Iran, and colleagues.

Gestational diabetes mellitus (GDM), a pregnancy complication, is characterised by carbohydrate intolerance and . Approximately 7% of all pregnancies in the United States are affected by GDM, but the prevalence ranges from 1 to 14% of all pregnancies in the world depending on the population studied and the diagnostic criteria used. GDM can increase the risk of pre-eclampsia, pre-term delivery and delivery by caesarean section.

"We are aware of no study that has examined the effect of joint calcium–vitamin D supplementation on insulin function, lipid profiles, inflammatory factors and biomarkers of oxidative stress in GDM," say the authors. "The current study was, therefore, done to investigate the effects of calcium plus vitamin D supplementation on metabolic status of with GDM."

This randomised placebo-controlled trial was performed on 56 women with GDM. Subjects were randomly assigned to receive calcium plus vitamin D supplements or placebo. Individuals in the calcium–vitamin D group (n=28) received 1000 mg calcium per day and 50000 IU (international units) vitamin D3 tablets two times during the study (at study baseline and day 21 of intervention) and those in the placebo group (n=28) received two placebos at the same time points. Fasting blood samples were taken at study baseline and after 6 weeks of intervention.

The authors found that, following the administration of plus vitamin D supplements, they observed significant reductions in fasting plasma glucose, insulin, and LDL or 'bad' cholesterol, as well as improvements in insulin sensitivity and increases in HDL or 'good' cholesterol, compared with those patients who took placebo.

The authors say: "Calcium plus vitamin D supplementation in GDM women had beneficial effects on ...this is important because elevated circulating levels of inflammatory markers and impaired insulin metabolism in GDM can predict the progression to type 2 diabetes (T2D) later in life and neonatal complications. Impaired insulin metabolism in women with GDM can result in adverse long term maternal outcomes and increased perinatal morbidity (babies large for gestational age, birth trauma, pre-eclampsia), and long-term consequences in the offspring. In addition, increased inflammatory markers in GDM might predict the future development of both metabolic and cardiovascular disease."

Explore further: Supplements of calcium and vitamin D may have too much for some older women

Related Stories

Supplements of calcium and vitamin D may have too much for some older women

June 18, 2014
Calcium and vitamin D are commonly recommended for older women, but the usual supplements may send calcium excretion and blood levels too high for some women, shows a new study published online today in Menopause, the journal ...

Raising low vitamin D levels lowers risk of prediabetes progressing to diabetes

June 23, 2014
Vitamin D and calcium supplementation along with diet and exercise may prevent type 2 diabetes in prediabetic individuals who have insufficient vitamin D in their bodies, a study from India suggests. The results were presented ...

Calcium and vitamin D improve cholesterol in postmenopausal women

March 5, 2014
Calcium and vitamin D supplements after menopause can improve women's cholesterol profiles. And much of that effect is tied to raising vitamin D levels, finds a new study from the Women's Health Initiative (WHI) just published ...

4.4 mmol/L is optimal fasting glucose cutoff for GDM screening

April 16, 2013
(HealthDay)—A fasting plasma glucose value of 4.4 mmol/L is the optimal cut point for determining which pregnant Chinese women need a 75-g 2-h oral glucose tolerance test offered at 24 to 28 weeks' gestation, according ...

Gestational diabetes ups costs of maternity care by one-third

January 22, 2013
(HealthDay)—Women with gestational diabetes mellitus (GDM) are significantly more likely to receive an emergency cesarean section, have their infant admitted to a neonatal care unit, and incur significantly higher maternity ...

Recommended for you

Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes

December 11, 2018
Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes.

Millions of low-risk people with diabetes may be testing their blood sugar too often

December 10, 2018
For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life.

Very low calorie diets trialled by NHS to tackle diabetes

December 7, 2018
Hundreds of thousands of people will receive NHS help to battle obesity and type 2 diabetes under radical action set out by Simon Stevens, Chief Executive of NHS England.

New therapeutic avenue for type 2 diabetes

December 6, 2018
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are ...

Subtype of immune B cells can delay type 1 diabetes onset in mice

December 6, 2018
A team of researchers at Baylor College of Medicine and the University of Michigan Medical School reports today in the JCI Insight that a subset of immune B cells, known as CD19+IgM+ B cells, can delay the onset of type 1 ...

Is the pancreas regeneration debate settled? An original theory renewed

December 5, 2018
A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.