Deppression with atypical features associated with obesity

June 4, 2014

Major depressive disorder (MDD) with atypical features (including mood reactivity where people can feel better when positive things happen in life, increased appetite or weight gain) appears to be associated with obesity.

MDD has tremendous public health impact worldwide. Obesity is another burden for . Understanding the mechanisms underlying the association between MDD and obesity is important.

The study (which had 5.5 years of follow-up) included 3,054 residents (average age nearly 50 years) from Lausanne, Switzerland. The main outcomes were changes in (BMI), waist circumference and during follow-up.

At baseline, 7.6 percent of participants met the criteria for MDD. Among the participants with MDD, about 10 percent had atypical and melancholic episodes, 14 percent had atypical episodes, 29 percent had melancholic episodes and 48 percent had unspecified episodes. MDD with atypical features was associated during the follow-up period with a higher increase in adiposity in terms of BMI, incidence of obesity and in both sexes, as well as fat mass in men. The study suggests the higher BMI increase in participants with MDD with atypical features also was not temporary and persisted after remission of the depressive episode.

"For the clinician, the atypical subtype deserves particular attention because this subtype is a strong predictor of adiposity. Accordingly, the screening of atypical features and, in particular, increased appetite in individuals with depression is crucial. The prescription of appetite-stimulating medication should be avoided in these patients and dietary measures during depressive episodes with atypical features are advocated." Aurélie M. Lasserre, M.D., of Lausanne University Hospital, Switzerland, and colleagues wrote in their JAMA Psychiatry article.

Explore further: Research explores markers of depression from childhood to adulthood

More information: JAMA Psychiatry. Published online June 4, 2014. DOI: 10.1001/jamapsychiatry.2014.411

Related Stories

Depression second leading cause of global disability burden

November 5, 2013

A study published this week in PLOS Medicine reports the most recent and comprehensive estimates on how much death and disability is attributable to depression, both world-wide and in individual countries and regions.

Depression linked to reduced temporofrontolimbic coupling

June 6, 2012

(HealthDay) -- Patients with remitted major depressive disorder (MDD) have reduced guilt-selective temporofrontolimbic coupling between the right superior anterior temporal lobe (ATL) and subgenual cingulate cortex and adjacent ...

Recommended for you

Study: Impulsivity may weigh down some people

January 20, 2017

Researchers at the Center for BrainHealth at The University of Texas at Dallas have found a link between having an impulsive personality and a high body mass index (BMI).

No silver bullet to beating obesity, study finds

January 10, 2017

As many seek to battle festive bulge in January, new research challenges previous findings that any single aspect of diet or lifestyle can be targeted to reduce the risk of obesity in adults with a high genetic risk of putting ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.