Screening can identify early-stage HCC but benefits unclear

June 20, 2014
Screening can identify early-stage HCC but benefits unclear

(HealthDay)—For patients with chronic liver disease, hepatocellular carcinoma (HCC) screening can identify patients at an earlier stage, but the benefits and harms of screening are unclear, according to a study published online June 16 in the Annals of Internal Medicine.

Devan Kansagara, M.D., from the Portland Veterans Affairs Medical Center in Oregon, and colleagues conducted a systematic literature review to examine the benefits and harms of for HCC in patients with . Twenty-two studies met the inclusion criteria.

The researchers found that evidence of the effects of screening was very low strength. Based on one large trial, periodic ultrasonographic screening correlated with decreased HCC mortality (rate ratio, 0.63), but methodological flaws limited the study. No survival benefit was seen with periodic α-fetoprotein screening in a trial involving patients with hepatitis B. Based on 18 observational studies, patients that underwent screening had earlier-stage HCC than patients who were diagnosed clinically, but the effects were confounded by lead- and length-time. No survival differences were found for shorter (three- to four-month) and longer (six- to 12-month) screening intervals, based on two trials. Screening harms were poorly studied.

"Screening tests can identify early-stage HCC, but whether systematic screening leads to a survival advantage over clinical diagnosis is uncertain," the authors write.

Explore further: Screening for liver cancer in patients with cirrhosis

More information: Abstract
Full Text
Editorial

Related Stories

Screening for liver cancer in patients with cirrhosis

April 1, 2014
In a systematic review and meta-analysis of 47 studies with 15,158 patients, Amit Singal (University of Texas Southwestern Medical Center) and colleagues found that patients with cirrhosis who underwent surveillance (via ...

Liver cancer screening highly beneficial for people with cirrhosis

May 5, 2014
Liver cancer survival rates could be improved if more people with cirrhosis are screened for tumors using inexpensive ultrasound scans and blood tests, according to a review by doctors at UT Southwestern Medical Center.

USPSTF: Evidence lacking for primary care suicide screening

May 20, 2014
(HealthDay)—The U.S. Preventive Services Task Force (USPSTF) has concluded that the current evidence is insufficient to evaluate the balance of benefits and harms of suicide screening in the primary care setting. These ...

Patient factors affect accuracy of AFP detection of liver cancer

May 4, 2014
(HealthDay)—Measurement of α-fetoprotein (AFP) detects hepatocellular carcinoma (HCC) most accurately in patients without hepatitis C virus (HCV) infection, according to a study published in the May issue of Clinical Gastroenterology ...

Studies of patients with cirrhosis uncover limitations in liver cancer screening

December 1, 2011
Two studies available in the December issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, have uncovered limitations in screening for primary liver cancer, also known as hepatocellular ...

New study suggests benefit of screening on breast cancer deaths

June 17, 2014
Invitation to modern mammography screening may reduce deaths from breast cancer by about 28 percent, suggests a study from Norway published in BMJ. This means that for every 10,000 women invited to screening, about 27 deaths ...

Recommended for you

Researchers develop swallowable test to detect pre-cancerous Barrett's esophagus

January 17, 2018
Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise ...

Scientists zoom in to watch DNA code being read

January 17, 2018
Scientists have unveiled incredible images of how the DNA code is read and interpreted—revealing new detail about one of the fundamental processes of life.

Presurgical targeted therapy delays relapse of high-risk stage 3 melanoma

January 17, 2018
A pair of targeted therapies given before and after surgery for melanoma produced at least a six-fold increase in time to progression compared to standard-of-care surgery for patients with stage 3 disease, researchers at ...

Dulling cancer therapy's double-edged sword

January 17, 2018
Researchers have discovered that killing cancer cells can actually have the unintended effect of fueling the proliferation of residual, living cancer cells, ultimately leading to aggressive tumor progression.

T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma

January 16, 2018
WASHINGTON-(Jan. 16, 2018)-Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. So, a research team that includes Children's National Health System clinician-researchers ...

More evidence of link between severe gum disease and cancer risk

January 16, 2018
Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.