Novel methods may help stem cells survive transplantation into damaged tissues

Novel methods may help stem cells survive transplantation into damaged tissues
Credit: 2014, Mary Ann Liebert, Inc., publisher

Stem cells offer much promise for treating damaged organs and tissues, but with current transplantation approaches stem cell survival is poor, limiting their effectiveness. New methods are being developed and tested to improve the survival and optimize their therapeutic function after transplantation, as described in a Review article in BioResearch Open Access.

In the article 'Preconditioning Stem Cells for In Vivo Delivery,' S├ębastien Sart, Ecole Polytechnique (Palaiseau, France) and Teng Ma and Yan Li, Florida State University (Tallahassee) examine the leading strategies for preconditioning prior to transplantation to prepare them for the environment often found in damaged tissue. Preconditioning methods might include exposing stem cells to microenvironments characterized by reduced oxygen levels, heat shock, and oxidative stress, creating three-dimensional stem cell aggregates or microtissues, and using hydrogels in which to embed or encapsulate the cells.

"This article provides an extensive review of the current methods of stem cell preconditioning for transplantation," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. "It also highlights the employed to do this."


Explore further

Inner ear stem cells hold promise for restoring hearing

More information: The article is available free on the BioResearch Open Access website.
Citation: Novel methods may help stem cells survive transplantation into damaged tissues (2014, July 22) retrieved 14 May 2021 from https://medicalxpress.com/news/2014-07-methods-stem-cells-survive-transplantation.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments