Cellular protein may be key to longevity

Cellular protein may be key to longevity
Credit: Aging cell

Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions known increase longevity.

Elevation of ATF4, at least in the liver, seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan.

"Pathways that appear to change in the same way in many different kinds of slow-aging may provide helpful hints towards the design of drugs that keep people healthy longer by slowing most of the diseases of aging," said Dr. Richard Miller, senior author of the Aging Cell study.

"ATF4 seems to be involved in control of aging from yeast to mice, so it's a good bet to be important in human aging, too."


Explore further

Experimental drug prolongs life span in mice

More information: Li, W., Li, X. and Miller, R. A. (2014), ATF4 activity: a common feature shared by many kinds of slow-aging mice. Aging Cell. doi: 10.1111/acel.12264
Journal information: Aging Cell

Provided by Wiley
Citation: Cellular protein may be key to longevity (2014, September 15) retrieved 20 July 2019 from https://medicalxpress.com/news/2014-09-cellular-protein-key-longevity.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more