More kids harmed by drinking in pregnancy than expected, study reports

More kids harmed by drinking in pregnancy than expected, study reports
Fetal alcohol spectrum disorders may affect about 5 percent of U.S. children.

(HealthDay)—Although drinking during pregnancy has long been considered taboo, new research suggests that as many as one in 20 U.S. children may have health or behavioral problems related to alcohol exposure before birth.

The study found that between 2.4 percent and 4.8 percent of children have some kind of , or FASD.

"Knowing not to drink during pregnancy and not doing so are two different things," especially before a woman knows she is pregnant, said lead researcher Philip May, a professor of public health at the University of North Carolina at Chapel Hill. He said the high prevalence of children affected by drinking during pregnancy may be due to social pressures or women's difficulty in changing their drinking habits.

Findings from the study were reported online Oct. 27 and in the November print issue of Pediatrics.

Fetal include fetal alcohol syndrome disorder plus other conditions that include some, but not all, of the characteristics of fetal alcohol syndrome, according to background information in the study.

Fetal alcohol syndrome is the most severe end of the spectrum, and children with this condition have abnormal facial features, structural brain abnormalities, growth problems and behavioral issues. Children on the less severe end of the spectrum may have impairments in the ability to complete tasks required to do well in school, or have behavioral issues, the study noted.

May and his colleagues selected a nationally representative town in the Midwest for the study. The town had an average annual alcohol consumption rate about 14 percent higher than the rest of the United States. That translated into roughly a liter of alcohol more per person per year, according to the study authors.

The town had 32 schools with a total of more than 2,000 first-graders. About 70 percent of the youngsters' parents allowed their children to participate in the study.

May's team identified first-graders who had a developmental problem or were below the 25th percentile for height, weight or head circumference. Then the researchers gave memory and thinking ("cognitive") tests, as well as behavioral tests, to these children and to a comparison group of typically developing first-graders.

The specially trained researchers also assessed the children for the physical attributes of fetal alcohol syndrome disorder, which include small eye openings, a smooth upper lip, a thin red border to the upper lip and smaller heads, May said.

The researchers found that six to nine of every 1,000 children had fetal alcohol syndrome. And, between 11 and 17 per 1,000 had partial , according to the study.

These numbers are higher than in previous research, but that may be due to the rigorous methods in the study, said Dr. Janet Williams, a professor of pediatrics at the University of Texas Health Science Center in San Antonio.

"FASD is an umbrella term covering the full spectrum of permanent lifelong conditions, ranging from mild to severe, and encompassing a broad variety of physical defects and cognitive, behavioral, emotional and adaptive functioning deficits," Williams said. "As we have better methodology, we're getting closer to the real prevalence, the real problem, and we need to stop the root cause of the problem."

This study also identified factors that predicted a higher risk that a child would have an FASD. The longer it took a mother to learn she was pregnant, how frequently she drank three months before pregnancy, and the more alcohol the child's father drank, the more likely it was that the child would have an FASD, the study found.

There are multiple reasons rates of FASDs are high, said Dr. Lana Popova, a senior scientist at the Centre for Addiction and Mental Health and an assistant professor of epidemiology and of social work at the University of Toronto.

"First and foremost, women are receiving mixed messages about alcohol use during pregnancy through their family or friends, health care providers and campaigns," Popova said. "Second, the rates of alcohol use, binge drinking and drinking during pregnancy appear to be increasing among young women in a number of countries."

A high number of unplanned pregnancies and a need to improve access to effective substance abuse treatment programs for women of childbearing age are two other contributing factors, Popova said.

"There is no safe amount of alcohol or safe time to drink during pregnancy, or when planning on becoming pregnant," she said. "If a woman is unaware of her pregnancy, for whatever reason, she should discontinue drinking immediately upon pregnancy recognition."

Williams added that researchers continue to study the effects of even small amounts of during because it is such a significant problem.

"Alcohol is a neurotoxin, and is the leading preventable cause of birth defects and intellectual and neurodevelopmental disabilities," she said. "So why is it worth experimenting with your child?"

Explore further

Researchers affirm dangers of drinking during pregnancy

More information: Learn more about fetal alcohol spectrum disorders from the U.S. Centers for Disease Control and Prevention.
Journal information: Pediatrics

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Oct 27, 2014
Prenatal Ethanol Exposure... Gene Expression, and Behavior in a Mouse Model... http://www.jneuro...abstract

"Changes in gene expression reported in this study may be caused by altered DNA methylation, an epigenetic modification that cells use to mediate gene expression (Moore et al., 2013), cell differentiation, and embryonic development (Monk et al., 1987; Feng and Fan, 2009)."

Is this not the way that cell type differentiation occurs in all cells of all individuals of all vertebrates and invertebrates?

If cell type differentiation is not RNA-directed via DNA methylation and RNA-mediated events that link the epigenetic landscape to the physical landscape of DNA in species from microbes to man, mutations and natural selection could replace genetic networks and metabolic networks and somehow lead to the evolution of diversity. Evolution could replace ecological speciation if there was a model for evolution.

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