Pre-angiography high-dose statins cut contrast-induced AKI

Pre-angiography high-dose statins cut contrast-induced AKI

(HealthDay)—For patients undergoing coronary angiography, pretreatment with high-dose statins reduces the risk of contrast-induced acute kidney injury (CIAKI), according to a meta-analysis published in the Nov. 1 issue of The American Journal of Cardiology.

Anene Ukaigwe, M.D., from the Reading Health System in Pennsylvania, and colleagues conducted a systematic review and meta-analysis of of short-term high-dose statins for CIAKI prevention in patients undergoing . Data were included from 12 randomized controlled trials involving 5,564 patients.

The researchers found that CIAKI occurred in 3.4 percent of patients pretreated with high-dose statins and in 7.6 percent of those pretreated with low-dose statin or placebo (odds ratio, 0.43; P < 0.001). In subgroup analysis, the correlation persisted for patients with diabetes (odds ratio, 0.60; P = 0.004) and in patients with documented (creatinine clearance <60 ml/min/m²; odds ratio, 0.66; P = 0.03).

"In conclusion, pretreatment with high-dose statins, compared with low-dose statins or placebo, in undergoing coronary angiography reduces the incidence of CIAKI," the authors write. "This benefit was seen irrespective of the presence of diabetes and chronic kidney disease. Future studies should identify optimum dosing protocols for each statin."


Explore further

Large variation in lipid reduction with high-dose statin tx

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: American Journal of Cardiology

Copyright © 2014 HealthDay. All rights reserved.

Citation: Pre-angiography high-dose statins cut contrast-induced AKI (2014, October 30) retrieved 19 November 2019 from https://medicalxpress.com/news/2014-10-pre-angiography-high-dose-statins-contrast-induced-aki.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments