Low levels of the DHEA prohormone predict coronary heart disease

November 10, 2014, University of Gothenburg

Men with low levels of DHEA in the blood run an increased risk of developing coronary heart disease events. The Sahlgrenska Academy study has been published in the Journal of the American College of Cardiology.

The term prohormone refers to the precursor of a hormone. DHEA is a prohormone that is produced by the adrenal glands and can be converted to active sex hormones. While the tendency of DHEA levels to fall with age was discovered long ago, the biological role of the prohormone is largely unknown.

Researchers at Sahlgrenska Academy, University of Gothenburg, have now shown that with low levels of DHEA in the blood run an increased risk of developing coronary events.

Lower level - greater risk

The study—which monitored 2,614 men age 69-80 in Gothenburg, Uppsala and Malmö for five years—assessed DHEA levels. The findings demonstrated that the lower the DHEA level at the study start, the greater the risk of coronary heart disease events during the five-year follow-up.

"Endogenous production of DHEA appears to be a protective factor against coronary heart disease," says Åsa Tivesten, who coordinated the study. "High DHEA levels may also be a biomarker of generally good health in elderly ."

Clear correlation

According to Professor Claes Ohlsson, "While the study establishes a clear correlation between DHEA in the blood and , the discovery does not indicate whether or not treatment with DHEA will reduce the risk in individual patients."

Explore further: Adrenal sex hormone level may predict heart disease risk

More information: "Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men" was published in the Journal of the American College of Cardiology on October 28. content.onlinejacc.org/article … px?articleid=1918789

Related Stories

Adrenal sex hormone level may predict heart disease risk

October 30, 2014
(HealthDay)—Blood levels of the adrenal sex hormone dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) may predict an increased risk of coronary heart disease (CHD) in elderly men, according to a study published in ...

Low steroid levels linked to increased risk of cardiovascular disease

June 23, 2012
Low levels of a naturally occurring steroid are associated with an increased risk of heart and blood-vessel disease in elderly men, a new study finds. The results will be presented Saturday at The Endocrine Society's 94th ...

Experts recommend against diagnosing testosterone deficiency in women

October 3, 2014
The Endocrine Society today issued a Clinical Practice Guideline (CPG) advising against the use of testosterone therapy in healthy women.

Adult day-care services boost beneficial stress hormones in caregivers

March 24, 2014
Family caregivers show an increase in the beneficial stress hormone DHEA-S on days when they use an adult day care service for their relatives with dementia, according to researchers at Penn State and the University of Texas ...

Blood test for Alzheimer's: Study identifies procedure that detects early stages

May 4, 2011
(Medical Xpress) -- A new blood test that will diagnose Alzheimer's disease may soon hit the market, thanks to an innovative study from the Research Institute of the McGill University Health Centre (MUHC). Their findings ...

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.