Genetic testing for personalized nutrition leads to better outcomes

Researchers from the University of Toronto (U of T) report that personalized dietary advice based on a person's genetic makeup improves eating habits compared to current "one-size-fits-all" dietary recommendations. The findings were published online today in the journal PLoS One.

"We conducted the first to determine the impact of disclosing DNA-based on eating habits," says Ahmed El-Sohemy, an Associate Professor in Nutritional Sciences at U of T and Canada Research Chair in Nutrigenomics. "We found that people who receive DNA-based advice improve their diet to a greater extent than those who receive the standard dietary advice. They're also the ones who need to change it the most."

Nutrigenomics is a field of research that aims to understand why some people respond differently than others to the same foods. Personalized nutrition, a branch of personalized medicine, is an application of that helps tailor to a person's DNA.

The researchers collected data on the intake of caffeine, sodium, vitamin C and sugar from 138 healthy young adults. The subjects were then randomized into two different study groups—one was given DNA-based dietary advice for each of the four of interest, and the other group was given current standard dietary advice for the same dietary components with no genetic information.

What is Nutrigenomix? Here's a primer. Credit: Nutrigenomix.com

Changes in their were assessed after three and 12 months. The researchers found that subjects who received DNA-based dietary advice started to show improvements to their diets after three months and the changes became even more apparent after 12 months.

Specifically, those who were informed that they carried a version of a gene linked to salt intake and high blood pressure significantly reduced their sodium intake, in accordance with the recommendation, compared to the group that received the standard advice for .

No effects were observed for the other components of the diet. However, most subjects were already meeting the dietary recommendations for the three other components at the start of the study, and the researchers believe this might explain why no significant changes were seen in these intakes.

"This study addresses some notable limitations in previous studies that attempted to measure the impact of disclosing genetic information on lifestyle changes," says El-Sohemy. "Previous studies focused on disease risk prediction rather than metabolic genes that affect specific components of the diet. This is the first time that the impact of dietary advice based on diet-related genes with specific actionable advice has been tested."

José M. Ordovás, Director of Nutrition and Genomics at Tufts University, who was not involved in the study, says personalized not only increases compliance, but also supports the long-term health of patients. "One of the major problems that we have found regarding one-size-fits-all dietary recommendations is people's adherence to them", says Ordovas, a Professor of Nutrition and Genetics. "This work supports the notion that DNA-based recommendations can be more beneficial for the individual and, in addition, will increase his or her compliance, which will increase our ability of preventing chronic diseases using dietary approaches."

The subjects in the study received dietary advice reports that were developed in collaboration with Nutrigenomix Inc., a U of T start-up company that develops genetic test kits for personalized nutrition only through qualified healthcare professionals.


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Journal information: PLoS ONE

Citation: Genetic testing for personalized nutrition leads to better outcomes (2014, November 14) retrieved 22 July 2019 from https://medicalxpress.com/news/2014-11-genetic-personalized-nutrition-outcomes.html
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JVK
Nov 14, 2014
It's nutritional epigenetics, not nutrigenomics

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

http://figshare.c...s/994281

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in..."

JVK
Nov 14, 2014
I've been blessed to be one of the first medical laboratory scientists to become involved with testing for links between genetic networks and metabolic networks. The testing uses evidence levels established at Vanderbilt to predict responses to different medications.

I am surprised to see an advertisement included in the medicalxpress news, but it encourages me to link to information about the serious science of personalized medicine that I expect to become a practice standard. I think this will happen long before advice on what to eat or not eat is helpful to the majority of people, who don't follow their physician's advice anyway.

After testing for how individual differences in genes and metabolism predict responses to medications, anyone who does not following their physician's advice may eliminate any concerns about what to eat.

See: Pharmacogenomics at Mayo Clinic https://www.youtu...G_9EEeeA

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