Genetic variant ups risk of graft-versus-host disease in HSCT
Effie W. Petersdorf, M.D., from University of Washington in Seattle, and colleagues first genotyped rs9277534 in 3,505 persons to define rs9277534-DPB1 haplotypes. Then, linkage of the rs9277534 A and G alleles to the mismatched HLA-DPB1 was determined among 1,441 recipients of transplants from HLA-A,B,C,DRB1,DQB1-matched unrelated donors with only one HLA-DPB1 mismatch. Quantitative polymerase chain reaction was used to assess HLA-DPB1 expression.
The researchers found that mean HLA-DPB1 expression was lower with rs9277534A than with rs9277534G. In the case of donors with rs9277534A-linked HLA-DPB1, the risk of acute GVHD was higher for recipients with rs9277534G-linked HLA-DPB1 mismatches than for recipients with rs9277534A-linked HLA-DPB1 mismatches (hazard ratio, 1.54; 95 percent confidence interval, 1.25 to 1.89; P < 0.001). Similarly, the risk of death due to causes other than disease recurrence was also higher for recipients with rs9277534G-linked HLA-DPB1 mismatches than for recipients with rs9277534A-linked HLA-DPB1 mismatches (hazard ratio, 1.25; 95 percent confidence interval, 1.00 to 1.57; P = 0.05).
"Among recipients of HLA-DPB1-mismatched transplants from donors with the low-expression allele, recipients with the high-expression allele had a high risk of GVHD," the authors write.
Editorial (subscription or payment may be required)
Copyright © 2015 HealthDay. All rights reserved.